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polyphosphoinositide phosphatase

Known as: Phosphatidylinositol 3,5-Bisphosphate 5-Phosphatase, EC 3.1.3.-, SAC Domain-Containing Protein 3 
Polyphosphoinositide phosphatase (907 aa, ~104 kDa) is encoded by the human FIG4 gene. This protein plays a role in the mediation of… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Alkaline PhosphatasePhosphoric Monoester Hydrolases
DephosphorylationEnzyme GeneEsterase GeneFIG4 gene

Papers overview

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Highly Cited
2016
Highly Cited
2016
Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors
Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases… 
Review
2014
Review
2014
Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research
Genetic insights into the pathophysiology of amyotrophic lateral sclerosis (ALS) are untangling the clinical heterogeneity that… 
Highly Cited
2005
Highly Cited
2005
Regulation of Intracellular Phosphatidylinositol‐4‐Phosphate by the Sac1 Lipid Phosphatase
Phosphatidylinositol 4‐phosphate (PtdIns(4)P) regulates diverse cellular processes, such as actin cytoskeletal organization… 
Highly Cited
2003
Highly Cited
2003
The Human Phosphatidylinositol Phosphatase SAC1 Interacts with the Coatomer I Complex*
The Saccharomyces cerevisiae SAC1 gene encodes an integral membrane protein of the endoplasmic reticulum (ER) and the Golgi… 
Review
2003
Review
2003
Endophilin and Synaptojanin Hook Up to Promote Synaptic Vesicle Endocytosis
Highly Cited
2002
Highly Cited
2002
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.
The Saccharomyces cerevisiae FAB1 gene encodes the sole phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinase responsible for… 
Highly Cited
2002
Highly Cited
2002
Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice
Synaptojanin 1 is a polyphosphoinositide phosphatase implicated in synaptic vesicle recycling. We used FM1-43 imaging and… 
Highly Cited
2001
Highly Cited
2001
PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.
Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin… 
Highly Cited
2000
Highly Cited
2000
Direct interaction of the 170 kDa isoform of synaptojanin 1 with clathrin and with the clathrin adaptor AP-2
Highly Cited
1996
Highly Cited
1996
Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.
Recent evidence has implicated caveolae/DIGs in various aspects of signal transduction, a process in which polyphosphoinositides… 
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