• Publications
  • Influence
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
  • M. Ehlers
  • Chemistry, Medicine
  • Neuron
  • 1 November 2000
Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted betweenExpand
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Recycling Endosomes Supply AMPA Receptors for LTP
Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors.Expand
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Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.
SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of excitatory synapses. Small microdeletions and point mutations in SHANK3 have been identified in a small subgroupExpand
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Characterization of Protein Kinase A and Protein Kinase C Phosphorylation of the N-Methyl-D-aspartate Receptor NR1 Subunit Using Phosphorylation Site-specific Antibodies*
Modulation of N-methyl-D-aspartate receptors in the brain by protein phosphorylation may play a central role in the regulation of synaptic plasticity. To examine the phosphorylation of the NR1Expand
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Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit
NMDA (N-methyl-D-aspartate) receptors are excitatory neurotransmitter receptors in the brain critical for synaptic plasticity and neuronal development. These receptors are Ca2+-permeableExpand
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Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
Both theoretical and experimental work have suggested that central neurons compensate for changes in excitatory synaptic input in order to maintain a relatively constant output. We report here thatExpand
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Molecular determinants of NMDA receptor internalization
Although synaptic AMPA receptors have been shown to rapidly internalize, synaptic NMDA receptors are reported to be static. It is not certain whether NMDA receptor stability at synaptic sites is anExpand
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In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2
Channelrhodopsin-2 (ChR2) is a light-gated, cation-selective ion channel isolated from the green algae Chlamydomonas reinhardtii. Here, we report the generation of transgenic mice that express aExpand
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Plasticity-Induced Growth of Dendritic Spines by Exocytic Trafficking from Recycling Endosomes
Dendritic spines are micron-sized membrane protrusions receiving most excitatory synaptic inputs in the mammalian brain. Spines form and grow during long-term potentiation (LTP) of synaptic strength.Expand
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Polarized Secretory Trafficking Directs Cargo for Asymmetric Dendrite Growth and Morphogenesis
Proper growth of dendrites is critical to the formation of neuronal circuits, but the cellular machinery that directs the addition of membrane components to generate dendritic architecture remainsExpand
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