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FIG4 gene

Known as: CMT4J, SAC DOMAIN-CONTAINING INOSITOL PHOSPHATASE 3, hSac3 
This gene plays a role in the metabolism of polyphosphoinositides.
National Institutes of Health

Related topics

Related topics

4 relations
DephosphorylationHydrolysisPhospholipid Metabolismpolyphosphoinositide phosphatase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Myelin abnormality in Charcot–Marie–Tooth type 4J recapitulates features of acquired demyelination
Charcot–Marie–Tooth type 4J (CMT4J) is a rare autosomal recessive neuropathy caused by mutations in FIG4 that result in loss of… 
2016
2016
Knockdown of the Drosophila FIG4 induces deficient locomotive behavior, shortening of motor neuron, axonal targeting aberration, reduction of life span and defects in eye development
2016
2016
FIG4 regulates lysosome membrane homeostasis independent of phosphatase function.
FIG4 is a phosphoinositide phosphatase that is mutated in several diseases including Charcot-Marie-Tooth Disease 4J (CMT4J) and… 
2014
2014
ALS‐associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases
FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal‐lysosomal pathway. Mutations of FIG4… 
2014
2014
Whole exome sequencing identifies three recessive FIG4 mutations in an apparently dominant pedigree with Charcot–Marie–Tooth disease
Review
2013
Review
2013
Fig4 deficiency: A newly emerged lysosomal storage disorder?
Highly Cited
2011
Highly Cited
2011
Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies
We previously reported that autosomal recessive demyelinating Charcot-Marie-Tooth (CMT) type 4B1 neuropathy with myelin… 
Highly Cited
2003
Highly Cited
2003
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.
In the budding yeast Saccharomyces cerevisiae, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is synthesized by a single… 
Highly Cited
2002
Highly Cited
2002
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.
The Saccharomyces cerevisiae FAB1 gene encodes the sole phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinase responsible for… 
Highly Cited
1993
Highly Cited
1993
Partial characterization of the Nicotiana tabacum actin gene family: Evidence for pollen-specific expression of one of the gene family members
The actin gene family of Nicotiana tabacum has been partially characterised by Southern hybridisation and by isolating λEMBL4… 
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