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plomestane

Known as: 19-acetylenic androstenedione, 10-PED, 10-Propargylestr-4-ene-3,17-dione 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

AndrostenedioneAntineoplastic AgentsAromatase InhibitorsPargyline

Narrower (1)

MDL 18962
analogs & derivatives

Papers overview

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2004
2004
Inhibition of growth and appearance of estrogen-dependent rat mammary tumors by 10-propargylestr-4-ene-3,17-dione, an aromatase inhibitor
SummaryThe aromatase inhibitor 10-propargylestr-4-ene-3,17-dione (PED) has been evaluatedin vivo as an anticancer agent… 
1995
1995
Enzyme-activated inhibitors of steroidal hydroxylases
1990
1990
Enzyme inactivation by potential metabolites of an aromatase-activated inhibitor (MDL 18,962).
MDL 18,962, 19-acetylenic androstenedione, is an enzyme-activated inhibitor of estrogen biosynthesis which is in Phase I clinical… 
1990
1990
The use of rat Leydig tumor (R2C) and human hepatoma (HEPG2) cells to evaluate potential inhibitors of rat and human steroid aromatase.
The efficacies of 10-propargylestr-4-ene-3,17-dione (PED), 4-hydroxyandrostenedione (4-OHA) and the imidazole broad spectrum… 
1989
1989
Human trophoblast xenografts in athymic mice: a model for peripheral aromatization.
1989
1989
19-Hydroxylase inhibition of adrenal mitochondrial P450 11 beta/18/19-hydroxylase by a suicide inhibitor.
19-Nor-deoxycorticosterone (19-nor-DOC) is a mineralocorticoid that is increased in some forms of experimental and human… 
1988
1988
Characterization of pregnant mare's serum gonadotropin-stimulated rat ovarian aromatase and its inhibition by 10-propargylestr-4-ene-3,17-dione.
1987
1987
Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative
1985
1985
Inhibition of Leydig tumor cell steroidogenesis by 10-propargylestr-4-ene-3,17-dione, an irreversible aromatase inhibitor.
The murine Leydig cell tumor (M5480A) was assayed for the presence of aromatase activity and for the effects of 10-propargylestr… 
Highly Cited
1981
Highly Cited
1981
10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.
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