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platensimycin

 
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Platensimycin (PTM) is a recently discovered broad-spectrum antibiotic produced by Streptomyces platensis. It acts by selectively… Expand
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Highly Cited
2011
Highly Cited
2011
Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and… Expand
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Highly Cited
2009
Highly Cited
2009
Platensimycin is the flagship member of a new and growing class of antibiotics with promising antibacterial properties against… Expand
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Highly Cited
2009
Highly Cited
2009
using a novel antibiotic assay approach. Characterization revealed a unique compact core connected to a highly oxygenated and… Expand
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2007
2007
Platensimycin is a novel Gram-positive broad spectrum antibiotic that inhibits bacterial growth by specifically and potently… Expand
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Highly Cited
2007
Highly Cited
2007
An efficient enantiocontrolled synthetic pathway to platensimycin has been developed. 
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2007
2007
An enantioselective route for the synthesis of oxatetracyclic core of platensimycin is reported for the first time using a 5-exo… Expand
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Highly Cited
2006
Highly Cited
2006
Bacterial infection remains a serious threat to human lives because of emerging resistance to existing antibiotics. Although the… Expand
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Highly Cited
2006
Highly Cited
2006
Reductive alkylation of 5-methoxy-1-tetralone (6) with 2,3-dibromopropene gave an equilibrium mixture of bicyclic diones 7 (51… Expand
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Highly Cited
2006
Highly Cited
2006
Fatty acids are essential for survival of bacteria and are synthesized by a series of enzymes including the elongation enzymes… Expand
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