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pirinixic acid

Known as: acetic acid, ((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-, (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetic acid, 4-chloro-6-(2,3-dimethylphenyl)amino-2-pyrimidinylthioacetic acid 
A synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (5)

Anticholesteremic AgentsCarcinogensMutagensPeroxisome Proliferators

Narrower (1)

WY 14,643

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity.
2010
2010
The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5…
The microsomal prostaglandin E2 synthase (mPGES)-1 is one of the terminal isoenzymes of prostaglandin (PG) E2 biosynthesis… 
2010
2010
Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Highly Cited
2008
Highly Cited
2008
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Dual inhibition of the prostaglandin (PG) and leukotriene (LT) biosynthetic pathway is supposed to be superior over single… 
2008
2008
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
A novel class of potent 5-lipoxygenase (5-LO) product synthesis inhibitors based on the structure of pirinixic acid (4-chloro-6… 
2008
2008
α‐Alkyl Substituted Pirinixic Acid Derivatives as Potent Dual Agonists of the Peroxisome Proliferator Activated Receptor Alpha and Gamma
Peroxisome proliferator‐activated receptors (PPAR) are nuclear receptors, playing a pivotal role in energy homeostasis… 
2007
2007
Quinoline-based derivatives of pirinixic acid as dual PPAR alpha/gamma agonists.
Pirinixic acid is known for its peroxisome proliferator-activated receptor (PPAR) agonistic action. In a recent publication, we… 
2003
2003
Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing…
We investigated the effects of acute (24-h) peroxisome proliferator-activated receptor (PPAR)alpha activation by WY14,643… 
2001
2001
Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis
1994
1994
Clofibrate and other peroxisomal proliferating agents relatively specifically inhibit synthesis of ethanolamine phosphoglycerides in cultured human fibroblasts.
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