pirfenidone

Known as: 5-methyl-1-phenyl-2-(1H)-pyridone 
An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2017
05010019822017

Papers overview

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Review
2016
Review
2016
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal disease that has long eluded therapy. Prognosis remains… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Idiopathic pulmonary fibrosis is a progressive and fatal lung disease with inevitable loss of lung function. The… (More)
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Highly Cited
2011
Highly Cited
2011
Pirfenidone is an oral antifibrotic agent that benefits diabetic nephropathy in animal models, but whether it is effective for… (More)
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Highly Cited
2010
Highly Cited
2010
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without proven effective therapy. A multicentre, double-blind… (More)
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Highly Cited
2008
Highly Cited
2008
Pirfenidone, a broad-spectrum antifibrotic agent, is known to have efficacy in certain fibrotic disease models, and is under… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Atrial fibrosis is an important substrate in atrial fibrillation (AF), particularly in the setting of structural heart… (More)
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Highly Cited
2005
Highly Cited
2005
Idiopathic pulmonary fibrosis (IPF) is a fatal disorder without an effective therapy to date. In a double-blind, randomized… (More)
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Highly Cited
2001
Highly Cited
2001
Fibrosis leads to chronic impairment of cardiac and renal function and thus reversal of existing fibrosis may improve function… (More)
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Highly Cited
1999
Highly Cited
1999
Idiopathic pulmonary fibrosis (IPF) is a progressive clinical syndrome of unknown etiology and fatal outcome. Currently available… (More)
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Highly Cited
1999
Highly Cited
1999
This study was undertaken to investigate whether treatment with the antifibrotic drug pirfenidone (PD) down-regulates the… (More)
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