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Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation.
BACKGROUND & AIMS Bacterial wall products play an important role in the activation of immune and nonimmune cells of the intestinal mucosa. Toll-like receptors (TLRs) TLR2 and TLR4 have beenExpand
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Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome
Objective Western lifestyle and diet are major environmental factors playing a role in the development of IBD. Titanium dioxide (TiO2) nanoparticles are widely used as food additives or inExpand
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Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo
The cathepsins D (CTSD), B (CTSB) and L (CTSL) are important for the intracellular degradation of proteins. Increased cathepsin expression is associated with inflammatory diseases. We have shownExpand
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Cell-cell contacts prevent anoikis in primary human colonic epithelial cells.
BACKGROUND & AIMS Colonic epithelial cells (CECs) receive important survival signals from the extracellular matrix and undergo detachment-induced apoptosis (anoikis) as soon as they lose theirExpand
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Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2.
BACKGROUND & AIMS Protein tyrosine phosphatase N2 (PTPN2) has been identified as a Crohn's disease (CD) candidate gene. However, a role for PTPN2 in the pathogenesis of CD has not been identified.Expand
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Succinate receptor mediates intestinal inflammation and fibrosis
Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates immune function. We analyze SUCNR1Expand
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Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients
Background Tumor necrosis factor alpha (TNF&agr;) is a proinflammatory cytokine and an important mediator in the pathophysiology of inflammatory bowel disease (IBD). The effects of TNF&agr; areExpand
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Subtractive screening reveals up‐regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages
Macrophages play a central role during the pathogenesis of inflammation. In normal intestinal mucosa surface expression of typical macrophage markers such as CD14, CD16, CD11b or T‐cellExpand
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Clinical Relevance of IgG Antibodies against Food Antigens in Crohn’s Disease: A Double-Blind Cross-Over Diet Intervention Study
Background: Environmental factors are thought to play an important role in the development of Crohn’s disease (CD). Immune responses against auto-antigens or food antigens may be a reason for theExpand
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Specific differences in migratory function of myofibroblasts isolated from Crohn's disease fistulae and strictures
Background: Recently we found that migration of colonic lamina propria fibroblasts in Crohn's disease patients (CD‐CLPF) from inflamed mucosa is significantly reduced as compared to control‐CLPF. TheExpand
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