pipermethystine

Starting from 3-hydroxy piperidines, a novel transition-metal free strategy to 5-hydroxy-5,6-dihydro-2(1H)pyridones is reported… Expand

Herbal hepatotoxicity by the anxiolytic kava (Piper methysticum Forst. f.) emerged unexpectedly and was observed in a few… Expand

One hallmark of Alzheimer's disease is the accumulation of amyloid β-peptide (AP), which can initiate a cascade of oxidative… Expand

The pyridone alkaloid pipermethystine has been considered to be responsible for alleged hepatoxicity of Kava products… Expand

Kava-containing products remain popular in the United States and continue to be sold in health food stores and ethnic markets… Expand

 

Kava herbal supplements have been recently associated with acute hepatotoxicity, leading to the ban of kava products in… Expand

Pipermethystine (1), 3alpha,4alpha-epoxy-5beta-pipermethystine (2) and awaine (3) were isolated from the aerial parts of kava… Expand

Kava herbal supplements have been recently associated with acute hepatotoxicity, leading to the ban of kava products in… Expand

[reaction: see text]. A novel enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones using a ring closing metathesis… Expand