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pipermethystine

National Institutes of Health

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Broader (1)

Pyridones

Papers overview

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2020
2020
Transition-Metal-Free Total Synthesis and Revision of the Absolute Configuration of Pipermethystine.
Starting from 3-hydroxy piperidines, a novel transition-metal free strategy to 5-hydroxy-5,6-dihydro-2(1H)pyridones is reported… Expand
Review
2011
Review
2011
Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits.
Herbal hepatotoxicity by the anxiolytic kava (Piper methysticum Forst. f.) emerged unexpectedly and was observed in a few… Expand
Highly Cited
2008
Highly Cited
2008
Kavalactones Protect Neural Cells against Amyloid β Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation
One hallmark of Alzheimer's disease is the accumulation of amyloid β-peptide (AP), which can initiate a cascade of oxidative… Expand
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2008
2008
Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?
The pyridone alkaloid pipermethystine has been considered to be responsible for alleged hepatoxicity of Kava products… Expand
Highly Cited
2007
Highly Cited
2007
Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats.
Kava-containing products remain popular in the United States and continue to be sold in health food stores and ethnic markets… Expand
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2005
2005
Stability and synergistic cytotoxicity of kavain and pipermethystine in kava methstycum
Highly Cited
2004
Highly Cited
2004
In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones.
Kava herbal supplements have been recently associated with acute hepatotoxicity, leading to the ban of kava products in… Expand
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Highly Cited
2003
Highly Cited
2003
Piperidine alkaloids from Piper methysticum.
Pipermethystine (1), 3alpha,4alpha-epoxy-5beta-pipermethystine (2) and awaine (3) were isolated from the aerial parts of kava… Expand
2003
2003
In Vitro Toxicity of Kava Alkaloid , Pipermethystine , in HepG 2 Cells as Compared to
Kava herbal supplements have been recently associated with acute hepatotoxicity, leading to the ban of kava products in… Expand
2001
2001
Facile enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones. First total synthesis of both enantiomers of pipermethystine.
[reaction: see text]. A novel enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones using a ring closing metathesis… Expand
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