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Biologically active and other chemical constituents of the herb of Hypericum perforatum L.
TLDR
These compounds are discussed with respect to structural features, their concentration, biological activities and their possible contribution to the clinically demonstrated antidepressant efficacy of extracts obtained from Hyperici herba. Expand
Cyanogenesis and the role of cyanogenic compounds in insects.
TLDR
The cyanogenic system comprising cyanogenic glycosides, hydroxynitriles (cyanohydrins), beta-glucosidases and nitrile lyases is widespread in the plant kingdom but also occurs in several arthropods, and their function as defensive compounds seems likely on the basis of their ability to generate HCN and their localization. Expand
Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity.
TLDR
Dose-response experiments of the total extract and of fractions rich in flavonoids and napthodianthrones produced inverted U-shaped dose response curves, which strongly suggested that dopamine mediated activity is important for the activity of the extract. Expand
The antibiotic principle of seeds of Moringa oleifera and Moringa stenopetala.
TLDR
4(α-L-Rhamnosyloxy)benzyl isothiocyanate was identified as an active antimicrobial agent form seeds of Moringa oleifera and M. stenopetala, but not pterygospermin as previously suggested. Expand
Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models.
TLDR
The present results clearly show that an SJW extract free of hyperforin and hypericin exerts antidepressant activity in behavioral models, supporting the working hypothesis that flavonoids are part of the constituents responsible for the therapeutic efficacy of SJW extracts. Expand
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).
TLDR
On the basis of the findings, it is likely that positive interactions between single compounds occur more frequently in traditionally used herbal preparations than is known presently. Expand
Cyanogenic allosides and glucosides from Passiflora edulis and Carica papaya.
TLDR
Differences in higher order effects in glucosides and allosides proved to be valuable for assignment of structures in this series and the assignment of C-2 stereochemistry of 1a/b was made in analogy to previous assignments in the glucoside series. Expand
Occurrence, variation and biosynthesis of the cyanogenic glucosides linamarin and lotaustralin in species of the Heliconiini (Insecta: Lepidoptera)
TLDR
The evidence suggests that both catabolism and anabolism of cyanoglucosides occurs during the pupal stage, and all stages of the life cycle of Heliconius itself are cyanogenic, with the highest concentration of cyanide in ova and higher concentrations in females than in males. Expand
Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test.
TLDR
The validity of a flavonoid fraction obtained from a crude extract of Hypericum perforatum was checked in open field experiments and in the FST after 12 days of daily treatment to exclude false positive results. Expand
Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test.
TLDR
The data indicate that naphthodianthrones are antidepressant constituents of H. perforatum and suggest that the dopaminergic system is involved in their action. Expand
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