pimonidazole

Known as: 2-((nitroimidazol-1-yl)methyl)-1-piperdineethanol, 1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)-, 2-pimonidazole 
A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The cellular response of malignant tumors to hypoxia is diverse. Several important endogenous metabolic markers are upregulated… (More)
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Highly Cited
2007
Highly Cited
2007
Obesity is linked to a variety of metabolic disorders, such as insulin resistance and atherosclerosis. Dysregulated production of… (More)
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Highly Cited
2003
Highly Cited
2003
The presence of hypoxia in tumours results in the overexpression of certain genes, which are controlled via the transcription… (More)
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Highly Cited
2002
Highly Cited
2002
Hypoxia is associated with tumor aggressiveness and is an important cause of resistance to radiation treatment. Assays of tumor… (More)
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Highly Cited
2000
Highly Cited
2000
The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns… (More)
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Highly Cited
1999
Highly Cited
1999
Pimonidazole binding was compared with oxygen electrode measurements and with measurements of the radiobiologically hypoxic… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Tumor hypoxia may be associated with treatment resistance, cell proliferation, and metastatic potential, which… (More)
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Highly Cited
1998
Highly Cited
1998
2-Nitroimidazoles, such as pimonidazole, are reduced in cells with low oxygen tension and are, therefore, used as hypoxia markers… (More)
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Highly Cited
1998
Highly Cited
1998
Hypoxia in human tumors is associated with poor prognosis, but the molecular mechanisms underlying this association are poorly… (More)
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Highly Cited
1995
Highly Cited
1995
Nitroimidazole markers of tumour hypoxia bind to normoxic liver and the question has been raised whether this is due to low… (More)
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