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pimonidazole

Known as: 2-((nitroimidazol-1-yl)methyl)-1-piperdineethanol, 1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)-, 2-pimonidazole 
A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

NitroimidazolesRadiation-Sensitizing Agents
Pimonidazole Hydrochloride

Narrower (2)

Ro 03-8799hypoxyprobe-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Quantitative Analysis of [18F]FMISO PET for Tumor Hypoxia: Correlation of Modeling Results with Immunohistochemistry
PurposeQuantitative evaluation of tumor hypoxia based on H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole ([18F]FMISO… 
2015
2015
Abstract B70: Combination of AT1R blockade with CD40 activation provides enhanced therapeutic efficacy for mouse pancreatic adenocarcinoma
Pancreatic ductal adenocarcinomas (PDAC) have a dense stroma -- rich in type I collagen and hyaluronan -- which compresses blood… 
2013
2013
Determination of the dynamics of tumor hypoxia during radiation therapy using biological imaging on mouse xenograft tumors
Background: Chronic, acute and hypoxemic hypoxia can lead to resistance to radiation therapy. The purpose of this thesis was to… 
2013
2013
Kinetics and mechanism of bioreduction of nitrimidazoles as hypoxia probes
Trabajo presentado al 21th Annual Meeting & Exhibition of International Society for Magnetic Resonance in Medicine, celebrado en… 
2013
2013
Non-Invasive Detection of Lactate as a Biomarker of Response using Spectral Selective Multiple Quantum Editing Sequence (SS-SelMQC)
Abstract : This application focuses on enhancing cancer care by developing non-invasive techniques to determine better biomarkers… 
2012
2012
Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease
In the present study, we tested whether polycystic kidney disease (PKD) is associated with renal tissue hypoxia and oxidative… 
2012
2012
Tumor pH and Vascularity in Human Prostate Cancer Models
Introduction: Tumor hypoxia and pH have been related to tumor aggressiveness, treatment response, and outcome. Here, we evaluated… 
2010
2010
Expression of angiotensin-converting enzyme 2 is increased during preservation injury of liver transplantation in rats: Expression of angiotensin-converting enzyme 2 is increased during preservation…
Review
2009
Review
2009
Clinical studies evidencing increased activities of the renin – angiotensin – aldosterone and sympathetic nervous systems in chronic kidney disease
In chronic kidney disease simultaneous activation of the renin–angiotensin and sympathetic systems occurs. Kidney ischemia seems… 
2004
2004
Autoradiographic distribution of [14C]-labelled pimonidazole in rhabdomyosarcoma-bearing rats and pigmented mice
SummaryThe hypoxic cell radiosensitizer [2-14C] pimonidazole (2-nitro-α-(piperidinomethyl)-l-imidazole ethanol) was injected i.p…