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pimonidazole

Known as: 2-((nitroimidazol-1-yl)methyl)-1-piperdineethanol, 1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)-, 2-pimonidazole 
A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

NitroimidazolesRadiation-Sensitizing Agents
Pimonidazole Hydrochloride

Narrower (2)

Ro 03-8799hypoxyprobe-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer
Background:The hypoxia marker pimonidazole is a candidate biomarker of cancer aggressiveness. We investigated the transcriptional… 
Highly Cited
2008
Highly Cited
2008
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
Background:Obesity is currently viewed as a state of chronic low-grade inflammation in which there is a pro-inflammatory… 
Highly Cited
2005
Highly Cited
2005
Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2…
Highly Cited
2005
Highly Cited
2005
Dependence of FDG uptake on tumor microenvironment.
Highly Cited
2000
Highly Cited
2000
Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis.
Highly Cited
1999
Highly Cited
1999
Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis.
Highly Cited
1998
Highly Cited
1998
Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.
BACKGROUND Tumor hypoxia may be associated with treatment resistance, cell proliferation, and metastatic potential, which… 
Highly Cited
1998
Highly Cited
1998
Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.
Hypoxia in human tumors is associated with poor prognosis, but the molecular mechanisms underlying this association are poorly… 
Highly Cited
1998
Highly Cited
1998
Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state.
2-Nitroimidazoles, such as pimonidazole, are reduced in cells with low oxygen tension and are, therefore, used as hypoxia markers… 
Highly Cited
1997
Highly Cited
1997
Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays.
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