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Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Human cancers exhibit strong phenotypic differences that can be visualized noninvasively by medical imaging. Radiomics refers to the comprehensive quantification of tumour phenotypes by applying aExpand
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and treatment response. Cellular adaptation to hypoxia occurs through multiple mechanisms, includingExpand
Corrigendum: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Corrigendum: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Machine Learning methods for Quantitative Radiomic Biomarkers
Radiomics extracts and mines large number of medical imaging features quantifying tumor phenotypic characteristics. Highly accurate and reliable machine-learning approaches can drive the success ofExpand
Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers.
BACKGROUND AND PURPOSE Tumor oxygenation is recognized as an important determinant of the outcome of radiotherapy and possibly also of other treatment modalities in a number of tumor types and inExpand
Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer.
Activation of the phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is associated with three major radioresistance mechanisms: intrinsic radioresistance; tumour-cell proliferation;Expand
Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy
Radiotherapy, an important treatment modality in oncology, kills cells through induction of oxidative stress. However, malignant tumors vary in their response to irradiation as a consequence ofExpand
Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients.
PURPOSE E-cadherin is a transmembrane glycoprotein, involved in cell-cell adhesion and epithelial-mesenchymal transition (EMT). Vimentin is highly expressed in mesenchymal cells and is positivelyExpand
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.
Hypoxia is associated with tumor aggressiveness and is an important cause of resistance to radiation treatment. Assays of tumor hypoxia could provide selection tools for hypoxia-modifying treatments.Expand
Reduction of observer variation using matched CT-PET for lung cancer delineation: a three-dimensional analysis.
PURPOSE Target delineation using only CT information introduces large geometric uncertainties in radiotherapy for lung cancer. Therefore, a reduction of the delineation variability is needed. TheExpand