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Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Extracellular pH (pH(e)) is lower in many tumors than in the corresponding normal tissue. The significance of acidic pH(e) in the development of metastatic disease was investigated in the presentExpand
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High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.
Pathophysiological parameters such as vascular density and tissue oxygen pressure can influence tumor malignancy and patient survival. Observations from our group showed that metastatic spread ofExpand
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Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging.
The aim of this study was to investigate whether apparent diffusion coefficients (ADCs) could be used as measures of cell density and necrotic fraction of tumors. Tumors of four human melanomaExpand
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Incidence of radiation-induced insufficiency fractures of the female pelvis: evaluation with MR imaging.
OBJECTIVE The purpose of this study was to assess the incidence, time of appearance, and evolution of radiation-induced insufficiency fractures of the female pelvis with MR imaging. SUBJECTS ANDExpand
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Interstitial fluid pressure and associated lymph node metastasis revealed in tumors by dynamic contrast-enhanced MRI.
Elevated interstitial fluid pressure (IFP) in tumors can cause metastatic dissemination and treatment resistance, but its study poses a challenge because of a paucity of noninvasive imagingExpand
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Fluctuating and Diffusion-Limited Hypoxia in Hypoxia-Induced Metastasis
Purpose: Most tumors develop regions with hypoxic cells during growth, owing to permanent limitations in oxygen diffusion (chronic or diffusion-limited hypoxia) and/or transient limitations in bloodExpand
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Microenvironment-induced cancer metastasis
  • E. Rofstad
  • Biology, Medicine
  • International journal of radiation biology
  • 1 January 2000
Purpose : To present and evaluate clinical data suggesting that cancer metastasis may be induced by the microenvironment of the primary tumour and to discuss possible mechanisms ofExpand
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Correlation of high lactate levels in head and neck tumors with incidence of metastasis.
Using quantitative bioluminescence imaging, tissue concentrations of ATP, glucose, and lactate were registered in biopsies that were taken from primary tumors of human head and neck at the time ofExpand
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Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor.
Clinical studies have shown that metastatic spread is associated with hypoxia in the primary tumor. The mechanism behind this association has not been identified and, in fact, it has not beenExpand
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Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts.
Interstitial fluid pressure (IFP) is elevated in many experimental and human tumors, and high IFP is associated with poor prognosis in human cancer. The significance of elevated IFP in theExpand
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