piericidin A1
National Institutes of Health
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Objective
In order to obtain piericidin intermediates of low toxicity by metabolic engineering, we studied the function of…
Objective: The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition…
We report a concise and convergent laboratory synthesis of the rare marine natural product lehualide B that has led to the…
Full details of the total synthesis of piericidin A1 and B1 and its extension to the preparation of a series of key analogues are…
Piericidin Bx TV-oxide was isolated from a culture broth of Streptomyces sp. as a novel inhibitor of phosphatidylinositol (PI…
The first total syntheses of piericidin A1 and B1 are disclosed and unambiguously establish the relative and absolute…