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Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization.
A novel inhibitor of protein tyrosine phosphatase, dephostatin, was isolated from the culture broth of a strain of Streptomyces and inhibited the growth of Jurkat cells. Expand
Saquayamycins, new aquayamycin-group antibiotics.
From the culture broth of Streptomyces nodosus MH190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A1). Expand
Biosynthetic studies of terpentecin.
Tetrodecamycin and dihydrotetrodecamycin, new antimicrobial antibiotics against Pasteurella piscicida produced by Streptomyces nashvillensis MJ885-mF8. I. Taxonomy, fermentation, isolation,
The novel antimicrobial antibiotic against Pasteurella piscicida, tetrodecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolated from the fermentation broth of StreptomycesExpand
A bleomycin-inactivating enzyme in mouse liver.
The bleomycin-inactivating enzyme of rat liver was separated from a known aminopeptidase B by Affinity chromatography of the extract on Sepharose 4 B-lysinamide gave 25-fold purified enzyme, but further purification vas not successful because of instability of the enzyme. Expand
Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.
Migrastatin inhibited spontaneous migration of human esophageal cancer EC17 cells and migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis. Expand
Isolation and characterization of terpentecin, a new antitumor antibiotic.
A new antitumor antibiotic, terpentecin was isolated from the culture broth of strain MF730-N6, and prolonged the survival period of mice bearing leukemia L-1210, P388 and Ehrlich ascites carcinoma. Expand
Mode of inhibition of coformycin on adenosine deaminase.
Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
Lactonamycin was isolated from a culture broth of Streptomyces rishiriensis and exhibited antimicrobial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. Expand
Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4. II. Structure determination.
The absolute structure of a new antibiotic lactonamycin is described. The NMR studies deduced one of four possible structures for the aglycon attached by a rhodinose through glycosidic bond. TheExpand