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phosphoramide mustard

One of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide… 
National Institutes of Health

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2 relations
NCIt Antineoplastic Agent Terminology

Broader (1)

Phosphoramide Mustards

Papers overview

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2004
2004
Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat
SummaryBy a sensitive and quantitative fluorometric assay, brain and plasma time-dependent concentration profiles were generated… 
Highly Cited
1986
Highly Cited
1986
Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide.
The role of glutathione (GSH) as a determinant of cellular sensitivity to the cytotoxic and DNA-damaging effects of… 
1985
1985
Kinetics of phosphoramide mustard hydrolysis in aqueous solution.
Hydrolysis of phosphoramide mustard was investigated using HPLC, 31P NMR, and GC-MS with specific deuterium labels. The… 
1985
1985
Hypersensitivity reaction to a metabolite of cyclophosphamide.
Highly Cited
1984
Highly Cited
1984
Plasma concentrations of 4-hydroxycyclophosphamide and phosphoramide mustard in patients repeatedly given high doses of cyclophosphamide in preparation for bone marrow transplantation.
Plasma half-life and area under the curve (AUC) values for cyclophosphamide were determined in patients given this agent iv at… 
Highly Cited
1984
Highly Cited
1984
Role of acrolein in cyclophosphamide teratogenicity in rat embryos in vitro.
Highly Cited
1983
Highly Cited
1983
Cytotoxic activity relative to 4-hydroxycyclophosphamide and phosphoramide mustard concentrations in the plasma of cyclophosphamide-treated rats.
Abstract Male rats were given cyclophosphamide (50 mg/kg, i.p.), and the plasma concentrations of 4-hydroxycyclophosphamide and… 
1982
1982
Analysis and excision of ring-opened phosphoramide mustard-deoxyguanine adducts in DNA.
The reaction products formed by reacting deoxyguanosine with phosphoramide mustard at pH 7.4 have been analyzed by high… 
1981
1981
Sister-chromatid exchange analyses in rodent maternal, embryonic and extra-embryonic tissues: transplacental and direct mutagen exposures.
1978
1978
Denaturation of cytochrome P-450 by cyclophosphamide metabolites.
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