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phosphoramide mustard

One of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

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Phosphoramide Mustards

Papers overview

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2016
2016
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice†.
Mechanisms underlying obesity-associated reproductive impairment are ill defined. Hyperinsulinemia is a metabolic perturbation… 
2004
2004
Cytochromes P 450 in the Bioactivation of Chemicals
The initial view that the cytochrome P450 enzyme system functions simply in the deactivation of xenobiotics is anachronistic on… 
2001
2001
Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
O6-Benzylguanine (BG) inactivates O6-alkylguanine-DNA alkyltransferase (AGT), resulting in an increase in the sensitivity of… 
1987
1987
Kinetics of hydrolysis in vitro of nornitrogen mustard, a metabolite of phosphoramide mustard and cyclophosphamide
A gas chromatographic (GC-ECD) method was developed for the determination of nornitrogen mustard (NOR) and its hydrolysis… 
Review
1983
Review
1983
Teratology testing: I. Development and status of short-term prescreens. II. Biotransformation of teratogens as studied in whole embryo culture.
The development and role of short-term prescreening tests have been described and discussed in the first section. In the second… 
1982
1982
Influence of diuretics on urinary general base catalytic activity and cyclophosphamide-induced bladder toxicity.
The influence of diuretics on the induction of bladder toxicity by cyclophosphamide was investigated in rats. Following ip… 
1981
1981
5-Fluoro- and 5-chlorocyclophosphamide: synthesis, metabolism, and antitumor activity of the cis and trans isomers.
In seeking analogues of cyclophosphamide (1) having improved antitumor activity by virtue of accelerated formation of the… 
1978
1978
Cross-linking of DNA in L1210 cells and nuclei treated with cyclophosphamide and phosphoramide mustard.
: Phosphoramide mustard, formed from cyclophosphamide in vivo and in vitro, may be the active metabolite of this drug. We have… 
1976
1976
Cyclic phosphoramide mustard (NSC-69945) derivatives of amino acids and peptides.
The possibilities offered by a combination of the "latency" and "carrier" principles were studied by joining the phosphoramide… 
1975
1975
Synthesis and antitumor activity of 6-trifluoromethylcyclophosphamide and related compounds.
In an attempt to increase the combined toxicity of the metabolic end-products [acrolein (4) and phosphoramide mustard (3)] from…