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Pharmacokinetics of busulfan: correlation with veno-occlusive disease in patients undergoing bone marrow transplantation
The tenfold variability in the busulfan AUC and the statistical association of increased AUC with the development of VOD suggest a possible role for therapeutic monitoring in this setting. Expand
Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers.
The plasma pharmacokinetics and urinary excretion of thalidomide have been evaluated in eight healthy male volunteers receiving a single oral dose of 200 mg, and it is suggested that the major route of elimination of th Khalidomide is nonrenal. Expand
Alkylating properties of phosphoramide mustard.
Deuterated analogs of the two metabolites have been synthesized and used to determine that alkylation proceeds directly via an aziridinium intermediate rather than a direct SN2 displacement of the chlorine atom. Expand
Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving
Unambiguous and sensitive methods based on gas chromatography-chemical ionization mass spectrometry have been developed to quantitate cyclophosphamide and two alkylating and cytotoxic metabolites,Expand
The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers.
It is concluded that local delivery of BCNU to brain tissue with this polymeric drug delivery system results in sustained high local concentrations ofBCNU which may be of value in the treatment of patients with brain tumors. Expand
High-performance liquid chromatographic assay for taxol in human plasma and urine and pharmacokinetics in a phase I trial.
A reverse-phase high-performance liquid chromatographic assay for taxol capable of detecting concentrations as low as 50 nM, which can be automated using readily available equipment is developed and performed pharmacologic studies of taxol during the conduct of a phase I trial of this compound. Expand
Effect of plasma and carboxylesterase on the stability, mutagenicity, and DNA cross-linking activity of some direct-acting N-nitroso compounds.
The effects of mouse plasma, human plasma, and purified porcine liver carboxylesterase on nitrosourea, nitrosamide, and nitrosocarbamate chemical stability, mutagenicity, and DNA cross-linkingExpand
Determination of busulfan in human plasma by gas chromatography with electron-capture detection.
The method has been applied to analyze the plasma versus time profile of busulfan in human subjects following administration of an oral dose of 4 mg/kg per day as a marrow ablative chemotherapy for bone marrow transplantation. Expand
Role of acrolein in cyclophosphamide teratogenicity in rat embryos in vitro.
The results suggest that acrolein plays a role in CP teratogenesis, but that the form in which it arrives at the teratogenically sensitive sites within the embryo is an important consideration in terms of the relative roles of acroleIn and phosphoramide mustard in CPTeratogenicity. Expand
Decomposition of BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) in aqueous solution.
BCNU, labelled with 14 C in the chloroethyl groups, decomposes in neutral aqueous solution to release half of its radioactivity as volatile products which are consistent with the existence of chloro methylcarbonium ions as reactive intermediates which would produce substituted nucleotides. Expand