phosphatidylinositol 3,5-diphosphate

Salmonella colonizes a vacuolar niche in host cells during infection. Maturation of the Salmonella-containing vacuole (SCV… (More)

Atg18 is essential for both autophagy and the regulation of vacuolar morphology. The latter process is mediated by… (More)

Membrane-bound phosphoinositides are signalling molecules that have a key role in vesicle trafficking in eukaryotic cells… (More)

The signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)), likely functions in multiple signaling pathways. Here… (More)

Phosphoinositide lipids regulate complex events via the recruitment of proteins to a specialized region of the membrane at a… (More)

BACKGROUND Sorting nexins (SNXs) are phox homology (PX) domain-containing proteins thought to regulate endosomal sorting of… (More)

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that is lost in many human tumors and… (More)

Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P(2)) was first identified as a non-abundant phospholipid whose levels increase… (More)

The Saccharomyces cerevisiae FAB1 gene encodes a 257-kD protein that contains a cysteine-rich RING-FYVE domain at its NH2… (More)

Inositol phospholipids play multiple roles in cell signalling systems. Two widespread eukaryotic phosphoinositide-based signal… (More)