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phosphatidylinositol 3,4-diphosphate

Known as: phosphatidylinositol 3,4-bisphosphate, 3,4-PIP2, PtdIns(3,4)P2 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phosphatidylinositol Phosphates
phosphoinositide-3,4-bisphosphate

Papers overview

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Highly Cited
1999
Highly Cited
1999
Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.
SH2-containing inositol 5'-phosphatase (SHIP) plays a negative regulatory role in hematopoietic cells. We have now cloned the rat… 
Highly Cited
1998
Highly Cited
1998
A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets*
The aggregation of human platelets is an important physiological hemostatic event contingent upon receptor-dependent activation… 
Highly Cited
1996
Highly Cited
1996
Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.
Application of nerve growth factor (NGF) to PC12 cells stimulates a programme of physiological changes leading to the development… 
Highly Cited
1995
Highly Cited
1995
Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion…
Thrombin-induced accumulation of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) but not of PtdIns(3,4,5,)P3 is strongly… 
Highly Cited
1992
Highly Cited
1992
Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide).
The protein tyrosine phosphatase (PTPase) inhibitor pervanadate (vanadyl hydroperoxide) stimulated protein tyrosine… 
Highly Cited
1991
Highly Cited
1991
Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate.
Highly Cited
1990
Highly Cited
1990
Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.
Highly Cited
1989
Highly Cited
1989
Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.
The ability of three pure types of bovine brain phospholipase C (PLC) and one pure rat liver PLC to utilize as substrates the… 
Highly Cited
1986
Highly Cited
1986
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.
When [3H]inositol-prelabelled rat parotid-gland slices were stimulated with carbachol, noradrenaline or Substance P, the major… 
Highly Cited
1985
Highly Cited
1985
Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands.
A complete separation of myo-inositol 1,4,5-[4,5-(32)P]trisphosphate prepared from human erythrocytes, and myo-[2-3H]inositol 1,3… 
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