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Fish is a scaffolding protein and Src substrate. It contains an amino-terminal Phox homology (PX) domain and five Src homology 3… Expand p47phox is a key cytosolic subunit required for activation of phagocyte NADPH oxidase. The X‐ray structure of the p47phox PX… Expand PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained… Expand ABSTRACT The PTEN gene is a tumor suppressor localized in the frequently altered chromosomal region 10q23. The tumor suppressor… Expand BACKGROUND
Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and… Expand BACKGROUND
The activation of protein kinase B (PKB, also known as c-Akt) is stimulated by insulin or growth factors and results… Expand The avian sarcoma virus 16 (ASV 16) is a retrovirus that induces hemangiosarcomas in chickens. Analysis of the ASV 16 genome… Expand The influence of inositol phosphates and phosphoinositides on the α isoform of the RAC-protein kinase B (RAC/PKB) was studied… Expand The production, survival, and function of monocytes and macrophages is regulated by the macrophage colony-stimulating factor (M… Expand Currently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years… Expand