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phosphatidylinositol 3,4-diphosphate

Known as: phosphatidylinositol 3,4-bisphosphate, 3,4-PIP2, PtdIns(3,4)P2 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2017
05101519852017

Related topics

Related topics

2 relations

Broader (1)

Phosphatidylinositol Phosphates
phosphoinositide-3,4-bisphosphate

Related mentions per year

Related mentions per year

1963-2018
1960198020002020
phosphatidylinositol 3,4-diphosphate
Phosphatidylinositol Phosphates
phosphoinositide-3,4-bisphosphate

Papers overview

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Highly Cited
2005
Highly Cited
2005
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
Generation and turnover of phosphoinositides (PIs) must be coordinated in a spatial- and temporal-restricted manner. The small… (More)
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Highly Cited
2002
Highly Cited
2002
Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase
An important class of phosphorylated phosphoinositides carrying a phosphate group at the 3' position of the inositol ring are… (More)
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Highly Cited
2002
Highly Cited
2002
High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate
The products of PI 3-kinase activation, PtdIns(3,4,5)P3 and its immediate breakdown product PtdIns(3,4)P2, trigger physiological… (More)
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Highly Cited
2000
Highly Cited
2000
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
3-Methyladenine which stops macroautophagy at the sequestration step in mammalian cells also inhibits the phosphoinositide 3… (More)
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Highly Cited
2000
Highly Cited
2000
Phosphorylation of the PTEN tail regulates protein stability and function.
The PTEN gene is a tumor suppressor localized in the frequently altered chromosomal region 10q23. The tumor suppressor function… (More)
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Highly Cited
1999
Highly Cited
1999
Structural insights into phosphoinositide 3-kinase catalysis and signalling.
Phosphoinositide 3-kinases (PI3Ks) are ubiquitous lipid kinases that function both as signal transducers downstream of cell… (More)
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Highly Cited
1998
Highly Cited
1998
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.
Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4… (More)
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Highly Cited
1997
Highly Cited
1997
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
BACKGROUND Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and… (More)
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Highly Cited
1997
Highly Cited
1997
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
BACKGROUND The activation of protein kinase B (PKB, also known as c-Akt) is stimulated by insulin or growth factors and results… (More)
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Highly Cited
1997
Highly Cited
1997
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.
The avian sarcoma virus 16 (ASV 16) is a retrovirus that induces hemangiosarcomas in chickens. Analysis of the ASV 16 genome… (More)
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