phosphoinositide-3,4-bisphosphate

Known as: PI(3,4)P2 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phosphatidylinositols
phosphatidylinositol 3,4-diphosphate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.
Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and solutes are internalized into cells… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to membrane traffic. Among the seven… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.
The TOR (target of rapamycin) proteins play important roles in nutrient signaling in eukaryotic cells. Rapamycin treatment… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that is lost in many human tumors and… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.
Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic actions of insulin including glucose uptake and… (More)
Is this relevant?
Review
2000
Review
2000
Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway.
Signal transduction through the B-cell antigen receptor (BCR) determines the fate of B lymphocytes during their development and… (More)
Is this relevant?
1999
1999
Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels.
1. G protein-gated inwardly rectifying K+ (GIRK) channels are activated independently by Gbetagamma and internal Na+ via… (More)
Is this relevant?
1998
1998
Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis.
To understand how phosphatidylinositol 3-kinase (PI3K) modulates cell structure and function, we examined the molecular and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.
Cell attachment to fibronectin stimulates the integrin-dependent interaction of p85-associated phosphatidylinositol (PI) 3-kinase… (More)
Is this relevant?
1989
1989
Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils.
We recently showed that phosphatidylinositol trisphosphate (PIP3) was present in a unique lipid fraction generated in neutrophils… (More)
Is this relevant?