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phosphoinositide-3,4-bisphosphate

Known as: PI(3,4)P2 
National Institutes of Health

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Broader (1)

Phosphatidylinositols
phosphatidylinositol 3,4-diphosphate

Papers overview

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Highly Cited
2017
Highly Cited
2017
mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate
Effects of a lipid signaling molecule depend on its subcellular location. Local specificity of growth signals The mechanistic… 
Highly Cited
2009
Highly Cited
2009
Ci-VSP Is a Depolarization-activated Phosphatidylinositol-4,5-bisphosphate and Phosphatidylinositol-3,4,5-trisphosphate 5′-Phosphatase*
Phosphoinositides are membrane-delimited regulators of protein function and control many different cellular targets. The… 
Highly Cited
2008
Highly Cited
2008
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34
Salmonella colonizes a vacuolar niche in host cells during infection. Maturation of the Salmonella-containing vacuole (SCV… 
Highly Cited
2003
Highly Cited
2003
Allosteric Activation of PTEN Phosphatase by Phosphatidylinositol 4,5-Bisphosphate*
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that is lost in many human tumors and… 
Highly Cited
2002
Highly Cited
2002
Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473
Using bone marrow derived mast cells from SH2-containing inositol-5-phosphatase (SHIP) +/+ and −/− mice, we found that the loss… 
Highly Cited
2001
Highly Cited
2001
Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5′-Phosphatase Catalytic Activity
ABSTRACT Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic actions of insulin including glucose… 
Highly Cited
1999
Highly Cited
1999
The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth
The Trk/Nerve Growth Factor receptor mediates the rapid activation of a number of intracellular signaling proteins, including… 
Highly Cited
1998
Highly Cited
1998
MSS4, a Phosphatidylinositol-4-phosphate 5-Kinase Required for Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae *
The Saccharomyces cerevisiae protein MSS4 is essential and homologous to mammalian phosphatidylinositol-4-phosphate (PI(4)P) 5… 
Highly Cited
1998
Highly Cited
1998
Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis.
To understand how phosphatidylinositol 3-kinase (PI3K) modulates cell structure and function, we examined the molecular and… 
Highly Cited
1998
Highly Cited
1998
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase
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