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phosphoinositide-3,4-bisphosphate

Known as: PI(3,4)P2 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phosphatidylinositols
phosphatidylinositol 3,4-diphosphate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to membrane traffic. Among the seven… 
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Highly Cited
2008
Highly Cited
2008
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34
Salmonella colonizes a vacuolar niche in host cells during infection. Maturation of the Salmonella-containing vacuole (SCV… 
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Highly Cited
2002
Highly Cited
2002
Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473
Using bone marrow derived mast cells from SH2-containing inositol-5-phosphatase (SHIP) +/+ and −/− mice, we found that the loss… 
Highly Cited
2001
Highly Cited
2001
Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5′-Phosphatase Catalytic Activity
  • T. Wada, T. Sasaoka, +8 authors Masashi Kobayashi
  • Molecular and Cellular Biology
  • 2001
  • Corpus ID: 35921904
ABSTRACT Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic actions of insulin including glucose… 
Highly Cited
1999
Highly Cited
1999
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic…
Because of the probable causal relationship between constitutive p210(bcr/abl) protein tyrosine kinase activity and… 
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Highly Cited
1998
Highly Cited
1998
MSS4, a Phosphatidylinositol-4-phosphate 5-Kinase Required for Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae *
The Saccharomyces cerevisiae protein MSS4 is essential and homologous to mammalian phosphatidylinositol-4-phosphate (PI(4)P) 5… 
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Highly Cited
1998
Highly Cited
1998
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
Glioblastomas are highly malignant tumors of the central nervous system that are resistant to radiation and chemotherapy [1]. We… 
Highly Cited
1998
Highly Cited
1998
Inactivation and dephosphorylation of protein kinase Bα (PKBα) promoted by hyperosmotic stress
To study the role of protein kinase B (PKB) in response to cellular stress, we examined PKBα activity following different stress… 
Highly Cited
1998
Highly Cited
1998
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase
ADP-ribosylation factors (ARFs) are small GTP-binding proteins that are regulators of vesicle trafficking in eukaryotic cells [1… 
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Highly Cited
1989
Highly Cited
1989
Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils.
We recently showed that phosphatidylinositol trisphosphate (PIP3) was present in a unique lipid fraction generated in neutrophils… 
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