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phosphatidylinositol 3,4-diphosphate

Known as: phosphatidylinositol 3,4-bisphosphate, 3,4-PIP2, PtdIns(3,4)P2 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phosphatidylinositol Phosphates
phosphoinositide-3,4-bisphosphate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Understanding PTEN regulation: PIP2, polarity and protein stability
The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling… 
Highly Cited
1999
Highly Cited
1999
The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4…
We have tested the binding specificities of the pleckstrin homology (PH) domains of protein kinase B (PKB) and GRP1 (general… 
Highly Cited
1998
Highly Cited
1998
Identification and analysis of PH domain‐containing targets of phosphatidylinositol 3‐kinase using a novel in vivo assay in yeast
Phosphatidylinositol 3‐kinase (PI3K) mediates a variety of cellular responses by generating PtdIns(3,4)P2 and PtdIns(3,4,5)P3… 
Highly Cited
1998
Highly Cited
1998
The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells*
The serine-threonine kinase Akt/PKB is activated downstream of phosphatidylinositol 3-kinase in response to several growth factor… 
Highly Cited
1998
Highly Cited
1998
The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2α*
The cellular effects of MCP-1 are mediated primarily by binding to CC chemokine receptor-2. We report here that MCP-1 stimulates… 
Highly Cited
1998
Highly Cited
1998
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase
Highly Cited
1998
Highly Cited
1998
A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets*
The aggregation of human platelets is an important physiological hemostatic event contingent upon receptor-dependent activation… 
Highly Cited
1997
Highly Cited
1997
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
Highly Cited
1996
Highly Cited
1996
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
The production, survival, and function of monocytes and macrophages is regulated by the macrophage colony-stimulating factor (M… 
Highly Cited
1985
Highly Cited
1985
Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands.
A complete separation of myo-inositol 1,4,5-[4,5-(32)P]trisphosphate prepared from human erythrocytes, and myo-[2-3H]inositol 1,3… 
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