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Inositol trisphosphate, a novel second messenger in cellular signal transduction
TLDR
Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
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Inositol phosphates and cell signalling
TLDR
The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
TLDR
It is reported here that micromolar concentrations of Ins1,4,5P3 release Ca2+ from a nonmitochondrial intracellular Ca2- store in pancreatic acinar cells, and the results strongly suggest that this is the same Ca1+ store that is released by acetylcholine.
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Back in the water: the return of the inositol phosphates
TLDR
Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.
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Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
TLDR
The results suggest that the earliest event in the stimulus-response pathway is the hydrolysis of polyphosphoinositides by a phosphodiesterase to yield inositol 1,4,5-trisphosphate and inositl 1, 4-bisph phosphate, which are subsequently hydrolysed to inositoli 1-phosphates and inposol.
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Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P2
TLDR
Specific conditions that enable preservation of several organellar membranes for the immunocytochemical detection of PtdIns4P are defined and evidence that the majority of this lipid resides in the plasma membrane is presented, where it is metabolically distinct from the steady-state plasma membrane pool of PTDIns(4,5)P2.
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PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity
TLDR
Depletion of both lipids was required to prevent PM targeting of proteins that interact with acidic lipids or activation of the transient receptor potential vanilloid 1 cation channel, and PI4P contributes to the pool of polyanionic lipids that define plasma membrane identity and to some functions previously attributed specifically to PI(4,5)P2, which may be fulfilled by a more generalpolyanionic lipid requirement.
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Nuclear lipid signalling
  • R. Irvine
  • Biology, Chemistry
    Nature Reviews Molecular Cell Biology
  • 1 May 2003
TLDR
The best characterized of the intranuclear lipids are the inositol lipids that form the components of a phosphoinositide–phospholipase C cycle, but this is just part of a complex picture that involves many other lipids and functions.
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Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
TLDR
Evidence is presented that in intact neutrophils a phosphatidylinositol-(4,5)bisphosphate-3-kinase seems to be the focal point through which agonists stimulate the formation of 3-phosphorylated inositol lipids.
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Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei.
TLDR
The data suggest that isolated rat-liver nuclei have an intranuclear inositol lipid metabolism mechanism utilizing enzymes and substrates equivalent to those found in cytosol and plasma membrane, and that there may be some, but not complete, compartmentalization of the components of the nuclear inositl cycle.
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