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philanthotoxin 343

Known as: PHTX 343, PHTX-343, philanthotoxin-343 
National Institutes of Health

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2 relations

Broader (2)

PhenolsPolyamines

Papers overview

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2008
2008
A stereoselective approach to the azaspiro[5.5]undecane ring system using a conjugate addition/dipolar cycloaddition cascade: application to the total synthesis of (+/-)-2,7,8-epi…
An efficient stereocontrolled route to the spirocyclic perhydrohistrionicotoxin derivative (+/-)-2,7,8-epi-PHTx (4) is described… 
2005
2005
The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism.
Philanthotoxin-343 (PhTX-343), a synthetic analogue of wasp toxin PhTX-433, is a noncompetitive antagonist at ionotropic… 
Review
2000
Review
2000
Natural and synthetic polyamines: modulators of signalling proteins.
Highly Cited
2000
Highly Cited
2000
Mechanism of Irk1 Channel Block by Intracellular Polyamines
Intracellular polyamines inhibit the strongly rectifying IRK1 potassium channel by a mechanism different from that of a typical… 
2000
2000
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.
PhTX-343 and PhTX-12, analogues of the natural polyamine wasp toxin PhTX-433, were synthesised in 40-60% yields as pure… 
1996
1996
Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids
1996
1996
Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343.
Acid-base properties (pKa values and proton distribution patterns) of philanthotoxin-343(PhTX-343) were investigated by 1H and… 
Review
1992
Review
1992
Arthropod toxins as leads for novel insecticides: an assessment of polyamine amides as glutamate antagonists.
1992
1992
Philanthotoxin-343 blocks long-term potentiation in rat hippocampus.
The effects of extracellularly-applied synthetic philanthotoxin-343 (PhTX-343) on transmission and long-term potentiation (LTP… 
1991
1991
Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes.
125I2-iodinated philanthotoxin-343 (PhTX-343), [125I2]PhTX-343-arginine, and [125I2]PhTX-343-lysine were synthesized and… 
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