phenylbutyrate

Known as: 4-phenylbutyrate, PBA 
An orally active derivative of the short-chain fatty acid butyrate with potential antineoplastic activity. 4-Phenylbutyrate inhibits histone… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2018
05010019672018

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Highly Cited
2011
Highly Cited
2011
OBJECTIVE Chronically elevated free fatty acids contribute to insulin resistance and pancreatic β-cell failure. Among numerous… (More)
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Highly Cited
2009
Highly Cited
2009
Chromatin modification through histone acetylation is a molecular pathway involved in the regulation of transcription underlying… (More)
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Highly Cited
2009
Highly Cited
2009
Recent studies have shown a link between obesity and endoplasmic reticulum (ER) stress. Perturbations in ER homeostasis cause ER… (More)
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Highly Cited
2005
Highly Cited
2005
Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding the huntingtin protein… (More)
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Highly Cited
2005
Highly Cited
2005
Multiple molecular defects trigger cell death in amyotrophic lateral sclerosis (ALS). Among these, altered transcriptional… (More)
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Highly Cited
2004
Highly Cited
2004
Sodium 4-phenylbutyrate (4-PBA) is a low molecular weight fatty acid that has been used for treatment of urea cycle disorders in… (More)
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Highly Cited
2004
Highly Cited
2004
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, characterized by degeneration of the anterior horn… (More)
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Highly Cited
1998
Highly Cited
1998
Sodium 4-phenylbutyrate (Buphenyl, 4PBA) is a new FDA approved drug for management of urea cycle disorders. We have previously… (More)
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Highly Cited
1997
Highly Cited
1997
The most common cystic fibrosis transmembrane conductance regulator mutation, delta F508-CFTR, is a partially functional chloride… (More)
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Highly Cited
1994
Highly Cited
1994
Intravenous arginine butyrate has been shown to increase fetal hemoglobin (HbF) in sickle cell and thalassemia patients. Recently… (More)
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