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phTX 12

Known as: PHTX-12, phTX12, philanthotoxin 12 
 
National Institutes of Health

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3 relations

Broader (2)

PolyaminesTyrosine
analogs & derivatives

Papers overview

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2016
2016
Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition
Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433… Expand
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2003
2003
A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues.
A general, improved procedure for rapid synthesis of philanthotoxin analogues, a pharmacologically important class of polyamine… Expand
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2002
2002
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.
Philanthotoxin-12 (PhTX-12) is a novel potent and selective, noncompetitive antagonist of nicotinic acetylcholine receptors… Expand
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2000
2000
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.
PhTX-343 and PhTX-12, analogues of the natural polyamine wasp toxin PhTX-433, were synthesised in 40-60% yields as pure… Expand
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2000
2000
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.
The modular structure of philanthotoxins was exploited for construction of the first combinatorial library of these compounds… Expand
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1994
1994
Philanthotoxin inhibits Ca2+ currents in rat hippocampal CA1 neurons.
The wasp venom philanthotoxin-4.3.3 (PhTX-4.3.3) is an antagonist of glutamate transmission in the insect as well as in the… Expand
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1992
1992
Synthesis of novel and photolabile philanthotoxin analogs : glutamate receptor antagonists
Abstract The synthetic methods for 27 novel and photolabile philanthotoxin analogs are described. Most analogs were synthesized… Expand
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