phTX 12

Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433… (More)

A general, improved procedure for rapid synthesis of philanthotoxin analogues, a pharmacologically important class of polyamine… (More)

The synthetic methods for 27 novel and photolabile philanthotoxin analogs are described. Most analogs were synthetized by two… (More)

PhTX-343 and PhTX-12, analogues of the natural polyamine wasp toxin PhTX-433, were synthesised in 40-60% yields as pure… (More)

The modular structure of philanthotoxins was exploited for construction of the first combinatorial library of these compounds… (More)

The wasp venom philanthotoxin-4.3.3 (PhTX-4.3.3) is an antagonist of glutamate transmission in the insect as well as in the… (More)