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pemetrexed disodium
Known as:
Disodium, Pemetrexed
The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses…
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5 relations
Narrower (2)
Alimta
LY 231514
NCIt Antineoplastic Agent Terminology
pemetrexed
pemetrexed disodium heptahydrate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The evolving role of pemetrexed disodium for the treatment of non-small cell lung cancer
G. Rossi
,
A. Alama
,
+7 authors
F. Grossi
Expert Opinion on Pharmacotherapy
2018
Corpus ID: 53033361
ABSTRACT Introduction: Non-small cell lung cancer (NSCLC) remains one of the big cancer killers, despite the introduction of a…
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Review
2012
Review
2012
Interstitial Pneumonitis after Treatment with Pemetrexed: A Rare Event?
A. Hochstrasser
,
Gabriel Benz
,
M. Joerger
,
A. Templeton
,
M. Brutsche
,
M. Früh
Chemotherapy
2012
Corpus ID: 188096
Background: Pneumonitis after pemetrexed has been rarely reported in conjunction with radiation therapy. Methods: Two cases of…
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2008
2008
Phase 2 trial of pemetrexed disodium and gemcitabine in advanced urothelial cancer (E4802)
R. Dreicer
,
Hailun Li
,
M. Cooney
,
G. Wilding
,
B. Roth
Cancer
2008
Corpus ID: 12486992
There is a need to identify active new regimens in patients with advanced urothelial cancer. Pemetrexed and gemcitabine are…
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2005
2005
Distribution of the Novel Antifolate Pemetrexed to the Brain
Haiqing Dai
,
Ying Chen
,
W. Elmquist
Journal of Pharmacology and Experimental…
2005
Corpus ID: 16110981
Pemetrexed disodium is a novel antifolate that exhibits potent inhibitory effects on multiple enzymes in folate metabolism. Phase…
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2005
2005
Cytotoxic effects of pemetrexed in gastric cancer cells
J. Kim
,
Keun-Wook Lee
,
+8 authors
Y. Bang
Cancer Science
2005
Corpus ID: 24896820
Pemetrexed is a newly developed multitargeted antifolate with promising clinical activity in many solid tumors including gastric…
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Highly Cited
2004
Highly Cited
2004
Antifolate Resistance in a HeLa Cell Line Associated With Impaired Transport Independent of the Reduced Folate Carrier
R. Zhao
,
S. Chattopadhyay
,
M. Hanscom
,
I. Goldman
Clinical Cancer Research
2004
Corpus ID: 24211659
Prior studies from this laboratory documented the prevalence of methotrexate (MTX) transport activity with a low pH optimum in…
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2002
2002
Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells.
E. Raymond
,
C. Louvet
,
+4 authors
C. Gespach
International Journal of Oncology
2002
Corpus ID: 25087544
Premetrexed disodium (MTA) is a novel multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase, and…
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Review
2001
Review
2001
Pemetrexed disodium, a novel antifolate with multiple targets.
N. Curtin
,
A. Hughes
The Lancet Oncology
2001
Corpus ID: 25435400
Highly Cited
2001
Highly Cited
2001
A phase II study of pemetrexed disodium (LY231514) in patients with locally recurrent or metastatic breast cancer.
D. Miles
,
I. Smith
,
R. Coleman
,
A. Calvert
,
M. Lind
European Journal of Cancer
2001
Corpus ID: 9390405
Review
2001
Review
2001
Pemetrexed disodium (Eli Lilly).
P. Norman
Current opinion in investigational drugs
2001
Corpus ID: 19453313
Pemetrexed, a thymidylate synthase (TS) and transferase inhibitor, is in phase III trials with Eli Lilly as a potential treatment…
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