pemetrexed disodium

Known as: Disodium, Pemetrexed 
The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses… (More)
National Institutes of Health

Papers overview

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Review
2005
Review
2005
In February 2004, pemetrexed disodium (Alimta; Eli Lilly), an anticancer drug that targets folate-dependent reactions that are… (More)
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2004
2004
In February 2004, pemetrexed disodium (Alimta; Eli Lilly), an anticancer drug that targets folate-dependent reactions that are… (More)
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2003
2003
BACKGROUND The purpose of this study was to evaluate ALIMTA (pemetrexed disodium, LY231514), a multi-targeted antifolate with… (More)
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2003
2003
BACKGROUND The aim of this study was to assess the activity of pemetrexed in patients with advanced gastric cancer. PATIENTS… (More)
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2002
2002
PURPOSE Pemetrexed disodium (Alimta, multitargeted antifolate, LY231514; Eli Lilly and Co., Indianapolis, Indiana) ("pemetrexed… (More)
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2002
2002
BACKGROUND To evaluate the efficacy and safety of pemetrexed therapy for chemotherapy-naïve patients with surgically incurable… (More)
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Review
2001
Review
2001
Pemetrexed disodium (ALIMTA), "pemetrexed") is a novel, multi-targeted antifolate that has demonstrated promising clinical… (More)
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Review
2001
Review
2001
Pemetrexed disodium is a potent new antifolate which inhibits many folate-dependent reactions that are essential for cell… (More)
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2001
2001
This phase II study determined response rate of patients with locally advanced or metastatic head and neck cancer treated with… (More)
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2000
2000
Purpose: To evaluate the population pharmacokinetics of pemetrexed disodium in cancer patients enrolled in four different open… (More)
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