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pemetrexed disodium

Known as: Disodium, Pemetrexed 
The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
BACKGROUND The purpose of this study was to evaluate ALIMTA (pemetrexed disodium, LY231514), a multi-targeted antifolate with… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND To evaluate the efficacy and safety of pemetrexed therapy for chemotherapy-naïve patients with surgically incurable… Expand
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Review
2001
Review
2001
Pemetrexed disodium (ALIMTA), "pemetrexed") is a novel, multi-targeted antifolate that has demonstrated promising clinical… Expand
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Review
2001
Review
2001
Pemetrexed disodium is a potent new antifolate which inhibits many folate-dependent reactions that are essential for cell… Expand
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Highly Cited
2001
Highly Cited
2001
Pemetrexed disodium (Alimta [Eli Lilly and Company, Indianapolis, IN], LY231514, multitargeted antifolate) is a new multitargeted… Expand
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Highly Cited
2001
Highly Cited
2001
This phase II study determined response rate of patients with locally advanced or metastatic head and neck cancer treated with… Expand
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Highly Cited
2001
Highly Cited
2001
A phase II study was conducted to evaluate the activity of pemetrexed in patients with locally recurrent or metastatic breast… Expand
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Highly Cited
2000
Highly Cited
2000
The aim of this study was to confirm the activity and assess the safety profile of multitargeted antifolate (MTA) for patients… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND To evaluate the activity of MTA plus cisplatin in chemotherapy-naive patients with non-small cell lung cancer (NSCLC… Expand
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Highly Cited
2000
Highly Cited
2000
PURPOSE To determine the safety and activity of LY231514 (ALIMTA, MTA, pemetrexed disodium, Eli Lilly and Co., Indianapolis, IN… Expand
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