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pasireotide

Known as: Pasireotida, Cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-), cyclo((4R)-4-(2-Aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-) 
A synthetic long-acting cyclic peptide with somatostatin-like activity. Pasireotide activates a broad spectrum of somatostatin receptors, exhibiting… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Importance Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are… Expand
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Review
2017
Review
2017
First-generation somatostatin receptors ligands (SRL) are the mainstay in the medical treatment of acromegaly, however the… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Postoperative pancreatic fistula is a major contributor to complications and death associated with pancreatic… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Many patients with acromegaly do not achieve biochemical control despite receiving high doses of the first-generation… Expand
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Highly Cited
2013
Highly Cited
2013
CONTEXT Pasireotide (SOM230) is a somatostatin analog with affinity for somatostatin receptor subtypes sst₁₋₃ and sst₅. Clinical… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Cushing's disease is associated with high morbidity and mortality. Pasireotide, a potential therapy, has a unique… Expand
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Highly Cited
2010
Highly Cited
2010
To the Editor: Cushing's disease, which is caused by an adrenocorticotropin-secreting pituitary adenoma, is associated with… Expand
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Highly Cited
2009
Highly Cited
2009
CONTEXT There is currently no medical therapy for Cushing's disease that targets the pituitary adenoma. Availability of such a… Expand
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE The clinically used somatostatin analogs, octreotide and lanreotide, act primarily by binding to somatostatin receptor… Expand
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Review
2008
Review
2008
Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor… Expand
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