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SOM-230

Known as: SOM 230, SOM230 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

pasireotide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility.
BACKGROUND Endometriosis is characterized by ectopic implantation of endometrial cells, which show increased proliferation and… 
2012
2012
Pasireotide (SOM230) protects the retina in animal models of ischemia induced retinopathies.
Review
2012
Review
2012
Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory?
Purpose of reviewTo give an overview of promising novel agents under development for the prevention and reduction of… 
2011
2011
Structural determinants of agonist-selective signaling at the sst(2A) somatostatin receptor.
The clinically used somatostatin (SS-14) analogs octreotide and pasireotide (SOM230) stimulate distinct species-specific patterns… 
2007
2007
Somatostatin receptor subtypes in human non-functioning neuroendocrine tumors and effects of somatostatin analogue SOM230 on cell proliferation in cell line NCI-H727.
Well-differentiated neuroendocrine tumors (NT) expresses somatostatin receptors (sstr). A composition of sstr subtype determines… 
Review
2007
Review
2007
Treatment of pituitary tumors
Somatostatin is an important physiological regulator of neuroendocrine function across multiple biological systems, including the… 
2006
2006
Treatment of neuroendocrine tumors with somatostatin analogs
Neuroendocrine tumors constitute a group of hormone producing tumors originating from neuroendocrine cells in different organs… 
Highly Cited
2005
Highly Cited
2005
Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats.
OBJECTIVE Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome is biochemically characterized by increased plasma… 
2005
2005
Short- and long-term effects of octreotide and SOM230 on GH, IGF-I, ACTH, corticosterone and ghrelin in rats.
SOM230 is a novel somatostatin analog which shows affinity to 4 of the 5 known somatostatin receptors (SSTR1-5). In binding… 
2005
2005
Early data on the efficacy and safety of the novel multi-ligand somatostatin analog, SOM230, in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR
8024 Background: SOM230 is a novel multi-ligand somatostatin analog that exhibits high binding affinity to four somatostatin… 
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