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SOM-230

Known as: SOM 230, SOM230 
National Institutes of Health

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Related topics

1 relation

Broader (1)

pasireotide

Papers overview

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Highly Cited
2012
Highly Cited
2012
Pasireotide (SOM230) shows efficacy and tolerability in the treatment of patients with advanced neuroendocrine tumors refractory or resistant to octreotide LAR: results from a phase II study.
Pasireotide (SOM230) is a novel multireceptor-targeted somatostatin (sst) analog with high binding affinity for sst receptor… 
Review
2010
Review
2010
Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy.
The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have increased in the past 20 years. GEP… 
Review
2009
Review
2009
Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours
Background  The discovery of somatostatin (SST) and the synthesis of a variety of analogues constituted a major therapeutic… 
Highly Cited
2009
Highly Cited
2009
Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial.
CONTEXT There is currently no medical therapy for Cushing's disease that targets the pituitary adenoma. Availability of such a… 
Review
2008
Review
2008
Pasireotide (SOM230): Development, mechanism of action and potential applications
  • H. Schmid
  • Molecular and Cellular Endocrinology
  • 2008
  • Corpus ID: 8975340
Highly Cited
2006
Highly Cited
2006
The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas.
CONTEXT There is no tumor-directed medical therapy available for Cushing's disease. OBJECTIVE The objective was to determine… 
Highly Cited
2005
Highly Cited
2005
Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells.
In a series of human corticotroph adenomas, we recently found predominant mRNA expression of somatostatin (SS) receptor subtype 5… 
Highly Cited
2004
Highly Cited
2004
Functional Activity of the Multiligand Analog SOM230 at Human Recombinant Somatostatin Receptor Subtypes Supports Its Usefulness in Neuroendocrine Tumors
Functional gastroenteropancreatic tumors express all 5 somatostatin receptor subtypes (sst) in different quantities. Octreotide… 
Highly Cited
2004
Highly Cited
2004
A single-dose comparison of the acute effects between the new somatostatin analog SOM230 and octreotide in acromegalic patients.
Treatment with the somatostatin receptor (sst) subtype 2 predominant analogs octreotide and lanreotide induces clinical and… 
Highly Cited
2002
Highly Cited
2002
SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile.
OBJECTIVE The aim of the present study was to identify a small, metabolically stable somatotropin release inhibiting factor (SRIF… 
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