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High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium.
CONTEXT Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. OBJECTIVE The objective of the study wasExpand
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The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
OBJECTIVE Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS We retrieved 43 consecutive patients with TSH-secreting pituitary tumorsExpand
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Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.
Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, andExpand
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Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
BACKGROUND Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. METHODS We performedExpand
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The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5.
OBJECTIVE Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing's disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity toExpand
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Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study.
To date, data on pituitary adenomas in MEN type 1 (MEN1) still have to be evaluated. We analyzed the data of a large series of 324 MEN1 patients from a French and Belgian multicenter study. Data onExpand
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Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study.
CONTEXT AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated pituitary adenomas and less often in sporadic cases. The clinical and therapeuticExpand
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Prolactinomas resistant to standard doses of cabergoline: a multicenter study of 92 patients.
BACKGROUND Dopamine agonist resistance in prolactinoma is an infrequent phenomenon. Doses of cabergoline (CAB) of up to 2.0 mg/week are usually effective in controlling prolactin (PRL) secretion andExpand
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The clinical, pathological, and genetic features of familial isolated pituitary adenomas.
Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively.Expand
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The epidemiology and genetics of pituitary adenomas.
According to data derived from autopsy and radiological imaging series, pituitary tumours occur very commonly in the general population; however, most of these tumours are incidental findings with noExpand
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