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Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells.
TLDR
A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine hypothalamic tissues and increased release of growth hormone, prolactin, corticotropin and luteinizing hormone from superfused rat pituitaries at as small a dose as 10(-10)M) or 10(-9)M (LH). Expand
Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.
TLDR
Adropinregulated expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma, a major regulator of lipogenesis, may be a factor governing glucose and lipid homeostasis, which protects against hepatosteatosis and hyperinsulinemia associated with obesity. Expand
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
TLDR
Modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding, and decreasing AMPK activity in the ventromedial nucleus of the hypothalamus (VMH) is sufficient to inhibit gh Relin's effects on FAS expression and feeding. Expand
Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.
TLDR
Results indicate that SSTR5 is critical for physiologic regulation of GH and TSH, and SRIF analogs with selective affinity for this receptor may therefore be more effective in the treatment of hormone-secreting pituitary adenomas. Expand
Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells.
TLDR
The data suggest that the sst5 protein, compared with sst2, is more resistant to glucocorticoids and might be a target for new therapeutic agents to treat Cushing's disease. Expand
Ghrelin in the regulation of body weight and metabolism
TLDR
The effects of ghrelin on glucose homeostasis, memory function and gastrointestinal motility have attracted considerable amount of attention and revealed novel therapeutic targets in treating a wide range of pathologic conditions. Expand
Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary
TLDR
Both SSTR2 and SSTR5 are involved in GH regulation in somatotroph adenoma cells, whereas Sstr5 exclusively regulates PRL secretion from prolactinomas cells, suggesting somatostatin analogues with improved selective binding affinity for these receptor subtypes may be effective in the treatment of either GH- or PRL-secreting adenomas. Expand
Adropin Deficiency Is Associated With Increased Adiposity and Insulin Resistance
TLDR
Serum adropin levels were high in chow‐fed conditions and were suppressed by fasting and diet‐induced obesity (DIO) and its functions impact on adiposity and are involved in preventing insulin resistance, dyslipidemia, and impaired glucose tolerance. Expand
Human somatostatin receptor subtypes in acromegaly: distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes.
TLDR
The quantitative expression of messenger ribonucleic acid for the 5 SSTR subtypes and the inhibitory effects of SRIF14; SRIF28; octreotide; the SSTR2-preferential analog, BIM-23197; and the S STR5-preferring analogs on GH and PRL secretion were analyzed, showing a highly variable ratio of the Sstr2 and SSTR5 transcripts, according to tumors. Expand
Bim-23244, a somatostatin receptor subtype 2- and 5-selective analog with enhanced efficacy in suppressing growth hormone (GH) from octreotide-resistant human GH-secreting adenomas.
TLDR
Data indicate that due to heterogeneous expression of SSTR2 and SSTR5 receptor subtypes, in GH-secreting tumors, a bispecific analog that can activate both receptors could achieve better control of GH hypersecretion in a larger number of acromegalic patients. Expand
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