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pancratistatin

A isoquinoline alkaloid from amaryllis with antineoplastic activity.
National Institutes of Health

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2 relations

Broader (2)

Amaryllidaceae AlkaloidsIsoquinolines

Papers overview

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Highly Cited
2009
Highly Cited
2009
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.
2009
2009
A flexible strategy based on a C2-symmetric pool of chiral substrates: concise synthesis of (+)-valienamine, key intermediate of (+)- pancratistatin, and conduramines A-1 and E.
A new strategy invoking a new application of the [3,3] sigmatropic rearrangement of allylic azides and the presence of a C(2… 
2008
2008
Suzuki cross-coupling/reductive debenzyloxycarbonylation sequence for the syntheses of [c]annulated isoquinolines: application for the syntheses of pancratistatin-like isoquinolines.
A two-step strategy involving Suzuki cross-coupling of boronic acids with a diverse array of alpha-iodoenones followed by… 
2008
2008
Sodium pancratistatin 3,4-o-cyclic phosphate, a water-soluble synthetic derivative of pancratistatin, is highly effective in a human colon tumor model.
Sodium pancratistatin 3,4- O-cyclic phosphate ( 2) is a novel water-soluble synthetic derivative of pancratistatin ( 1), a… 
2006
2006
Cyclotrimerization approach to unnatural structural modifications of pancratistatin and other amaryllidaceae constituents — Synthesis and biological evaluation
The phenanthridone core of pancratistatin lacking all aromatic oxygenation was prepared by cyclotrimerization of acetylene… 
2005
2005
Cyclotrimerization strategy toward analogues of amaryllidaceae constituents. synthesis of deoxygenated pancratistatin core.
[chemical reaction: see text]. A derivative of pancratistatin having no oxygenation in the aromatic ring was synthesized by a new… 
2005
2005
Induction of Apoptotic Cell Death Specifically in Rat and Human Cancer Cells by Pancratistatin
The major challenge in the battle against cancer is the specific targeting of cancer cells. Most chemotherapeutics and… 
Highly Cited
2004
Highly Cited
2004
Synthesis and biological activity of some structural modifications of pancratistatin.
2004
2004
An approach to pancratistatins via ring-closing metathesis: efficient synthesis of novel 1-aryl-1-deoxyconduritols F. cv.
Structurally novel cyclitols, 1-aryl-1-deoxyconduritols F, were efficiently prepared from d-xylose, utilizing RCM as a key step… 
1991
1991
Oversaturated solutions of drug in hydroxypropylcyclodextrins: parenteral preparation of pancratistatin.
The effect of 15 cyclodextrin derivatives (polar-electroneutral, cationic, anionic, and lipophilic) and of three 2… 
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