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Micro‐RNA‐31 controls hair cycle‐associated changes in gene expression programs of the skin and hair follicle
TLDR
It is shown that global miRNA expression in the skin markedly changes during distinct stages of the hair cycle in mice, and that expression of miR‐31 markedly increases during anagen and decreases during catagen and telogen.
GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation.
TLDR
It is demonstrated that the potent, irreversible and selective PPARgamma antagonist GW9662 prevented activation of PPARGamma and inhibited growth of human mammary tumour cell lines, and this data support the existence of PPargamma-independent pathways and question the central belief that PPAR Gamma ligands mediate their anticancer effects via activation of the receptor.
GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation
TLDR
It is demonstrated that the potent, irreversible and selective PPARγ antagonist GW9662 prevented activation of PPARαγ and inhibited growth of human mammary tumour cell lines, and this data support the existence of PParγ‐independent pathways and question the central belief that PP ARγ ligands mediate their anticancer effects via activation ofPPARγ.
Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations.
TLDR
Surprisingly, the majority of the hepatocytes generated during compound-induced hyperplasia were protected from apoptosis during liver regression, providing in vivo evidence to support the hypothesis that non-genotoxic hepatocarcinogens such as CPA and the peroxisome proliferators suppress apoptosis.
MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.
TLDR
The results suggest that MMP-10 is expressed and active at high levels in human NSCLC compared to normal lung tissues, and, as such, is a potential target for the development of novel therapeutics for lung cancer treatment.
Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.
TLDR
Levels of CYP1B1 were higher in tumor vasculature than that of the normal colon and indicate the caution that should be observed when developing such drugs.
The rodent non-genotoxic hepatocarcinogen Nafenopin and EGF alter the mitosis/apoptosis balance promoting hepatoma cell clonal growth.
TLDR
Sub-populations with differing growth kinetics suggesting selective clonal expansion via an alteration in the balance between mitosis and apoptotic cell death is revealed, suggesting genetic changes may have superseded such factor-dependence.
Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity1
TLDR
Construction of single-chain TNF molecule, a TNF mutant consisting of three TNF monomers fused by short peptide linkers is reported, which was found to possess increased stability in vitro and in vivo, and displayed reduced systemic toxicity yet slightly enhanced antitumoral activity in mouse models.
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