panadiplon

A new €32 million project aimed at understanding drug-induced liver injury is the latest of several collaborative efforts that… Expand

Ethanol's ability to enhance GABA neurotransmission via GABA(A) receptors has been implicated as an important mechanism… Expand

AbstractPurpose. To develop an integrated absorption model for estimating the fraction of dose absorbed and determining the… Expand

5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5] imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide) (RWJ-51204… Expand

Preclinical drug safety evaluation studies, typically conducted in two or more animal species, reveal and define dose-dependent… Expand

The benzodiazepine receptor ligand U-78875 [3-(5-cyclopro pyl-1,2, 4-oxadiazol-3-yl)-5-(1-methylethyl)imidazol(1, 5-a)quinoxalin… Expand

The quinoxalinone anxiolytic, panadiplon, was dropped from clinical development due to unexpected hepatic toxicity in human… Expand

The quinoxalinone anxiolytic, panadiplon, produces hepatic metabolic inhibition (mitochondrial impairment), microvesicular… Expand

The non-benzodiazepine anxiolytic, panadiplon, was discontinued from clinical development due to evidence of hepatic toxicity in… Expand

SummaryAnxiety disorders are common psychiatric problems and the cause of considerable morbidity. Following the demise of the… Expand