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panadiplon

Known as: 3-(5-cyclopropyl-1,2,4-oxadiazol 3-yl)-5-(1-methylethyl)imidazo(1,5-a)quinoxalin-4(5H)-one 
 
National Institutes of Health

Papers overview

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2012
2012
  • Alisa Opar
  • Nature Reviews Drug Discovery
  • 2012
  • Corpus ID: 37258153
A new €32 million project aimed at understanding drug-induced liver injury is the latest of several collaborative efforts that… Expand
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2005
2005
Ethanol's ability to enhance GABA neurotransmission via GABA(A) receptors has been implicated as an important mechanism… Expand
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Highly Cited
2004
Highly Cited
2004
AbstractPurpose. To develop an integrated absorption model for estimating the fraction of dose absorbed and determining the… Expand
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2002
2002
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5] imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide) (RWJ-51204… Expand
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Review
2001
Review
2001
Preclinical drug safety evaluation studies, typically conducted in two or more animal species, reveal and define dose-dependent… Expand
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1999
1999
The benzodiazepine receptor ligand U-78875 [3-(5-cyclopro pyl-1,2, 4-oxadiazol-3-yl)-5-(1-methylethyl)imidazol(1, 5-a)quinoxalin… Expand
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1998
1998
The quinoxalinone anxiolytic, panadiplon, was dropped from clinical development due to unexpected hepatic toxicity in human… Expand
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1996
1996
The quinoxalinone anxiolytic, panadiplon, produces hepatic metabolic inhibition (mitochondrial impairment), microvesicular… Expand
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1995
1995
The non-benzodiazepine anxiolytic, panadiplon, was discontinued from clinical development due to evidence of hepatic toxicity in… Expand
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1994
1994
SummaryAnxiety disorders are common psychiatric problems and the cause of considerable morbidity. Following the demise of the… Expand
  • table I
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