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panadiplon

Known as: 3-(5-cyclopropyl-1,2,4-oxadiazol 3-yl)-5-(1-methylethyl)imidazo(1,5-a)quinoxalin-4(5H)-one 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

OxadiazolesQuinoxalines

Narrower (1)

U 78875

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Overtaking the DILI Model-T
  • Alisa Opar
  • Nature Reviews Drug Discovery
  • 2012
    • Corpus ID: 37258153
A new €32 million project aimed at understanding drug-induced liver injury is the latest of several collaborative efforts that… Expand
2005
2005
Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys.
Ethanol's ability to enhance GABA neurotransmission via GABA(A) receptors has been implicated as an important mechanism… Expand
Highly Cited
2004
Highly Cited
2004
An Integrated Model for Determining Causes of Poor Oral Drug Absorption
  • L. Yu
  • Pharmaceutical Research
  • 2004
    • Corpus ID: 5910972
AbstractPurpose. To develop an integrated absorption model for estimating the fraction of dose absorbed and determining the… Expand
2002
2002
5-Ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N- (2-fluorophenyl)carboxamide (RWJ-51204), a New Nonbenzodiazepine Anxiolytic
5-Ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5] imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide) (RWJ-51204… Expand
2001
2001
Discriminative stimulus effects of panadiplon (U-78875), a partial agonist at the benzodiazepine site, in pentobarbital-trained rhesus monkeys.
The pentobarbital-like discriminative stimulus effects of the benzodiazepine receptor partial agonist panadiplon were assessed in… Expand
1999
1999
Drug discrimination analysis of partial agonists at the benzodiazepine site. I. Differential effects of U-78875 across training conditions in baboons and rats.
The benzodiazepine receptor ligand U-78875 [3-(5-cyclopro pyl-1,2, 4-oxadiazol-3-yl)-5-(1-methylethyl)imidazol(1, 5-a)quinoxalin… Expand
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1998
1998
Disruption of mitochondrial activities in rabbit and human hepatocytes by a quinoxalinone anxiolytic and its carboxylic acid metabolite.
The quinoxalinone anxiolytic, panadiplon, was dropped from clinical development due to unexpected hepatic toxicity in human… Expand
1996
1996
Potentiation of hypoxic injury in cultured rabbit hepatocytes by the quinoxalinone anxiolytic, panadiplon.
The quinoxalinone anxiolytic, panadiplon, produces hepatic metabolic inhibition (mitochondrial impairment), microvesicular… Expand
1995
1995
Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic.
The non-benzodiazepine anxiolytic, panadiplon, was discontinued from clinical development due to evidence of hepatic toxicity in… Expand
1994
1994
Anxiolytic Potential of Benzodiazepine Receptor Partial Agonists
SummaryAnxiety disorders are common psychiatric problems and the cause of considerable morbidity. Following the demise of the… Expand
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