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Conditioned place preference using opiate and stimulant drugs: A meta-analysis
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
An animal model of cocaine relapse shows that AMPA and NMDA receptors in the nucleus accumbens have opposing roles in the reinstatement of cocaine-seeking behavior, and indicates that the glutamatergic pathway from the mPFC to the nucleus Accumbens plays an important role in cocaine priming-induced reinstate of drug seeking.
Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.
- T. Khroyan, R. L. Barrett-Larimore, J. Rowlett, R. Spealman
- Psychology, BiologyThe Journal of pharmacology and experimental…
- 1 August 2000
The results suggest that D1- and D2-like receptors play fundamentally different roles in the relapse process, and either stimulation or blockade of D1 -like receptors appears to be inhibitory with respect to relapse.
Environmental enrichment attenuates locomotor sensitization, but not in vitro dopamine release, induced by amphetamine
Attenuation of Behavioral Effects of Cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in Squirrel Monkeys: Comparison with Dizocilpine
- Buyean Lee, D. Platt, J. Rowlett, A. S. Adewale, R. Spealman
- Psychology, BiologyJournal of Pharmacology and Experimental…
- 1 March 2005
The findings point to a significant contribution of mGluR5 mechanisms in the behavioral effects of cocaine related to its abuse and suggest that MPEP has properties of a functional cocaine antagonist, which are not secondary to antagonism at NMDA receptors.
The effect of environmental enrichment on amphetamine-stimulated locomotor activity, dopamine synthesis and dopamine release
Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development
DA partial agonists, in particular the D3-selective and the D1-like partial agonist, offer a more encouraging profile for novel anti-cocaine medications, and are often less severe and only observed at doses above those that antagonize the effects of cocaine.
Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior
Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.
- J. Rowlett, D. Platt, S. Lelas, J. Atack, G. Dawson
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 18 January 2005
The results provide evidence in nonhuman primates that alpha1GABAA receptors do not play a key role in the anxiolytic and muscle-relaxant properties of benzodiazepine-type drugs; instead, these effects involve alpha2GabAA, alpha3GABaa, and/or alpha5GAB AA subtypes.