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Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and Human
TLDR
Quantitative real-time polymerase chain reaction and Western blot analyses indicate that the pattern of CES tissue expression in monkey is similar to that of human, but the CES expression in dog is unique, with no detectable expression of CES in the intestine.
Prediction of Renal Transporter Mediated Drug-Drug Interactions for Pemetrexed Using Physiologically Based Pharmacokinetic Modeling
TLDR
The in vitro to in vivo extrapolation approach used in this work was developed to predict possible drug-drug interactions that may occur after coadministration of pemetrexed and nonsteroidal anti-inflammatory drugs (NSAIDs), and it included in vitro assays, risk assessment models, and physiologically based pharmacokinetic (PBPK) models.
Iodine in milk and meat of dairy cows fed different amounts of potassium iodide or ethylenediamine dihydroiodide.
TLDR
Relationships between I intake by lactating Holstein cows and iodine concentrations in milk and meat were investigated and moderate changes in dietary I are quickly reflected in milk I, but I in meat is relatively stable.
Ethnic Variability in the Expression of Hepatic Drug Transporters: Absolute Quantification by an Optimized Targeted Quantitative Proteomic Approach
TLDR
It is suggested that hepatic OATP expression alone does not explain the increased systemic statin levels in Asians compared with Caucasians, and this findings may help improve physiologically based pharmacokinetic modeling to predict statin pharmacokinetics profiles and enable extrapolation of pharmacokinetically data of OatP substrates across ethnic groups.
The effects of high and low energy density diets on satiety, energy intake, and eating time of obese and nonobese subjects.
TLDR
Data support the concept of time-energy displacement, which should have applicability to the treatment and prevention of obesity, and obese and nonobese subjects were comparable in their satiety ratings, energy consumption, eating time, and food acceptance.
Prediction of Transporter‐Mediated Drug‐Drug Interactions for Baricitinib
TLDR
Physiologically based pharmacokinetic modeling reproduced the renal clearance of baricitinib and the inhibitory effect of probenecid and suggested clinically relevant drug‐drug interactions (DDIs) with ibuprofen and diclofenac are unlikely.
Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier
TLDR
In situ BBB permeability of these solutes appeared to be primarily dependent on their lipophilicity in the absence of efflux transport, and in situ brain uptake clearance correlated with the intrinsic transcellular passive permeability from in vitro transport and cellular accumulation studies.
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