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pactimibe

National Institutes of Health

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Related topics

2 relations

Broader (1)

Indoleacetic Acids

Narrower (1)

pactimibe sulfate

Papers overview

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2012
2012
Inhibition of PCSK9 in familial hypercholesterolaemia
2011
2011
The ezetimibe Jonah: the trials and tribulations of an unlucky drug
Napoleon was once asked what quality he desired most in his generals. He replied luck. Napoleonic era navies also feared the… 
2010
2010
Novel acyl-CoA: cholesterol acyltransferase inhibitor: indoline-based sulfamide derivatives with low lipophilicity and protein binding ratio.
To find a novel acyl-CoA: cholesterol acyltransferase inhibitor, a series of sulfamide derivatives were synthesized and evaluated… 
2010
2010
Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation.
To find a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with anti-lipid peroxidative activity, a series of… 
2008
2008
Novel Binding Mode of the Acidic CYP2D6 Substrates Pactimibe and Its Metabolite R-125528
Typical CYP2D6 substrates generally contain a basic nitrogen atom that interacts with Asp301 and/or Glu216 and an aromatic moiety… 
2008
2008
CYP2D6-Mediated Metabolism of a Novel Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor, Pactimibe, and Its Unique Plasma Metabolite, R-125528
Pactimibe sulfate is a novel acyl coenzyme A:cholesterol acyltransferase inhibitor. We conducted metabolic studies of pactimibe… 
2006
2006
Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation…
2006
2006
Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe.
2006
2006
Pactimibe stabilizes atherosclerotic plaque through macrophage acyl-CoA:cholesterol acyltransferase inhibition in WHHL rabbits.
2006
2006
Multiple mechanisms of hypocholesterolemic action of pactimibe, a novel acyl-coenzyme A:cholesterol acyltransferase inhibitor.
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