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pactimibe

National Institutes of Health

Papers overview

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2011
2011
Napoleon was once asked what quality he desired most in his generals. He replied luck. Napoleonic era navies also feared the… 
Highly Cited
2009
Highly Cited
2009
CONTEXT Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol… 
Review
2009
Review
2009
CYP2D6 accounts for only a small percentage of total hepatic CYPs (<2%), but it metabolizes approximately 25% of clinically used… 
2008
2008
Typical CYP2D6 substrates generally contain a basic nitrogen atom that interacts with Asp301 and/or Glu216 and an aromatic moiety… 
2008
2008
Pactimibe sulfate is a novel acyl coenzyme A:cholesterol acyltransferase inhibitor. We conducted metabolic studies of pactimibe… 
Highly Cited
2006
Highly Cited
2006
BACKGROUND The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some…