H. Shirahase

Publications125
h-index19
Citations1,161
Highly Influential Citations10
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Endothelium‐dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2
TLDR
In conclusion, SP at 10−8 m induces EDC via endothelial NK1 receptors and TXA2 production, and SP at10−7 m induces EIC via NK2 receptors in the rabbit intrapulmonary artery.
Comparative study of vascular relaxation and receptor binding by PACAP and VIP
Endothelium-dependent contraction and -independent relaxation induced by adenine nucleotides and nucleoside in the canine basilar artery.
TLDR
The order of agonist potency for contraction was ATP greater than ADP much greater than AMP = adenosine, but for producing relaxation the agonists were equipotent, and the relaxation in response to ATP was attenuated by removal of the endothelium.
Endothelium‐Dependent Contraction Produced by Acetylcholine and Relaxation Produced by Histamine in Monkey Basilar Arteries
An endothelium‐dependent contraction in canine mesenteric artery caused by caffeine
TLDR
It is demonstrated that caffeine causes an EDC in canine mesenteric artery and suggested that the EDCF mediating this response is probably not arachidonic acid metabolites, endothelin or superoxide, and that caffeine‐induced EDC may be due to activation of the phospholipase D pathway.
Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice—possible dysfunction of receptor and/or receptor–G protein coupling
TLDR
ACh-induced endothelium-dependent relaxation is impaired in diabetic db/db mice, probably due to the dysfunction of ACh receptors and/or receptor–G protein coupling.
Inhibitory effects of trimetazidine dihydrochloride on aggregation, serotonin release and malondialdehyde production in rabbit platelets.
TLDR
The present results suggest that TMZ may inhibit the process preceding the cyclooxygenase pathway in the AA cascade, and subsequently may attenuate the aggregation and the serotonin release via thromboxane A2 production from endogenous AA.
Insulin sensitization by a novel partial peroxisome proliferator-activated receptor γ agonist with protein tyrosine phosphatase 1B inhibitory activity in experimental osteoporotic rats.
TLDR
The results suggest that the hypolipidemic effects of KY-201 are similar to those of rosiglitazone, but with less adverse effects, due to the combination of PPARγ partial activation and PTP1B inhibition.
NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.
Possible Role of Endothelial Thromboxane A2 in the Resting Tone and Contractile Responses to Acetylcholine and Arachidonic Acid in Canine Cerebral Arteries
TLDR
It is concluded that TXA2 is produced in the endothelial cells and may be involved in maintaining the resting tone and contractile response to AA in the canine cerebral artery.
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