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Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
The results identify several novel loci associated with plasma lipids that are also associated with CAD and provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
Genome-wide association study of blood pressure and hypertension
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7.
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
A meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, finds a long tail of additional common variant loci explaining much of the variation in susceptibility to type 2 diabetes.
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
The first GWA analysis of loci affecting total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform establishes 22 loci associated with serum lipid levels at genome-wide significance level.
Simvastatin with or without ezetimibe in familial hypercholesterolemia.
In patients with familial hypercholesterolemia, combined therapy with ezetimibe and simVastatin did not result in a significant difference in changes in intima-media thickness, as compared with simvastatin alone, despite decreases in levels of LDL cholesterol and C-reactive protein.
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Six previously unknown loci associated with fasting insulin at P < 5 × 10−8 in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals are presented.
Efficacy of statins in familial hypercholesterolaemia: a long term cohort study
- J. Versmissen, Daniëlla M. Oosterveer, E. Sijbrands
- MedicineBMJ : British Medical Journal
- 11 November 2008
Lower statin doses than those currently advised reduced the risk of coronary heart disease to a greater extent than anticipated in patients with familial hypercholesterolaemia.
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
A significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association is observed, and considerable improvements in the fine-mapping resolution of common variant association signals at several T1D susceptibility loci are observed.