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ormaplatin

Known as: tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))Platinum, 1,2-diaminocyclohexane tetrachloroplatinum(IV), Tetraplatin 
A platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Antineoplastic AgentsCross-Linking ReagentsOrganoplatinum Compounds
DNA CrosslinkingNCIt Antineoplastic Agent Terminology

Narrower (1)

NSC 363812

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Intracellular glutathione and cytotoxicity of platinum complexes
Although there have been a number of reports correlating cellular GSH levels with cytotoxicity of platinum agents, none has… 
Highly Cited
2001
Highly Cited
2001
The in vitro antitumour profile of some 1,2-diaminocyclohexane organotin complexes.
1998
1998
Catalytic Hydrogenolysis of Biphenylene with Platinum, Palladium, and Nickel Phosphine Complexes
The catalytic hydrogenolysis of biphenylene was carried out using Pt, Pd, and Ni phosphine complexes under an atmosphere of H2… 
1996
1996
Novel trans platinum complexes: comparative in vitro and in vivo activity against platinum-sensitive and resistant murine tumours.
Two pairs of cis/trans platinum complexes, JM118 (cis-ammine(cyclohexylamine) dichloro platinum(II)) and its trans counterpart… 
1995
1995
A sensitive postcolumn derivatization/UV detection system for HPLC determination of antitumor divalent and quadrivalent platinum complexes.
A sensitive postcolumn derivatization/UV detection system has been developed for HPLC analysis of antitumor divalent and… 
1994
1994
Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexylamine-platinum(IV) in comparison to cisplatin and tetraplatin in the rat.
This study compared the effect on sensory nerve conduction velocity in the hind limb of chronically treated age-matched rats of a… 
1993
1993
The role of metallothionein, glutathione, glutathione S-transferases and DNA repair in resistance to platinum drugs in a series of L1210 cell lines made resistant to anticancer platinum agents.
1993
1993
Modulation of cytotoxicity and cellular pharmacology of 1,2-diaminocyclohexane platinum (IV) complexes mediated by axial and equatorial ligands.
Isomers (R,R-, S,S-, and cis-) of 1,2-diaminocyclohexane (DACH) platinum(IV) complexes with selected axial and equatorial ligands… 
1991
1991
An unexpected biotransformation pathway for tetrachloro-(d,l-trans)-1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) in the L1210 cell line.
Tetrachloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) has been considered a prodrug which would be converted… 
1988
1988
Comparative toxicity and renal distribution of the platinum analogs tetraplatin, CHIP, and cisplatin at equimolar doses in the Fischer 344 rat.
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