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ormaplatin

Known as: tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))Platinum, 1,2-diaminocyclohexane tetrachloroplatinum(IV), Tetraplatin 
A platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which… Expand
National Institutes of Health

Papers overview

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Review
2007
Review
2007
The development of photoactivatable prodrugs of platinum-based antitumor agents is aimed at increasing the selectivity and hence… Expand
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Highly Cited
1996
Highly Cited
1996
Loss of DNA mismatch repair occurs in many types of tumors. The effect of the loss of DNA mismatch repair activity on sensitivity… Expand
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Highly Cited
1996
Highly Cited
1996
The present study was designed to explore the activity of platinum compounds in cisplatin-resistant cell lines, the unselected… Expand
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Highly Cited
1995
Highly Cited
1995
Carboxylation of hydroxide coordinated to Pt(1V) by anhydrides, pyrocarbonates, and isocyanates to form the corresponding Pt(1V… Expand
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Review
1993
Review
1993
  • L. Kelland
  • Critical reviews in oncology/hematology
  • 1993
  • Corpus ID: 5005091
Over the past two decades, platinum-based drugs (cisplatin and, latterly, the less toxic analogue carboplatin) have conferred… Expand
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Highly Cited
1993
Highly Cited
1993
The cytotoxicity of a novel platinum(IV) complex, bis-acetato-amminedichloro-cyclohexylamine platinum(IV) (JM216), has been… Expand
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Highly Cited
1993
Highly Cited
1993
The in vitro cytotoxicity, protein binding, partitioning of platinum from whole blood into erythrocytes, its exchange back into… Expand
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Highly Cited
1992
Highly Cited
1992
The role of glutathione (GSH) in the effectiveness of and resistance to 7 platinum compounds [5 Pt(II) and 2 Pt(IV) drugs] was… Expand
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Highly Cited
1991
Highly Cited
1991
The role of glutathione (GSH) and GSH-S-transferase (GST) activity in modulating the cytotoxicity of four platinum drugs and… Expand
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Highly Cited
1987
Highly Cited
1987
Human ovarian cancer cell lines with stable cisplatin resistance have been developed by chronic exposure of the parent cisplatin… Expand
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