ormaplatin

Known as: tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))Platinum, 1,2-diaminocyclohexane tetrachloroplatinum(IV), Tetraplatin 
A platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Oxaliplatin (4 mg/kg), cisplatin (2 mg/kg with 20 mg/kg mannitol) and ormaplatin (2 mg/kg) were administered i.p. twice weekly… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • table 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The present study was designed to explore the activity of platinum compounds in cisplatin-resistant cell lines, the unselected… (More)
Is this relevant?
1994
1994
Ormaplatin (tetraplatin, NSC 363812) is a platinum(IV) analogue that is active against cisplatin-resistant cell lines in… (More)
  • figure 1
  • table 1
  • table 3
  • table 2
  • figure 2
Is this relevant?
Review
1993
Review
1993
Over the past two decades, platinum-based drugs (cisplatin and, latterly, the less toxic analogue carboplatin) have conferred… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
The role of glutathione (GSH) in the effectiveness of and resistance to 7 platinum compounds [5 Pt(II) and 2 Pt(IV) drugs] was… (More)
  • table 1
  • figure 2
  • table 1
  • table 2
  • table 3
Is this relevant?
1992
1992
We have developed panels of human lung cancer cell lines with acquired and inherent resistance to cisplatin. Three parental cell… (More)
  • figure 1
  • figure 2
  • table 1
  • table 3
  • table 2
Is this relevant?
Highly Cited
1991
Highly Cited
1991
The role of glutathione (GSH) and GSH-S-transferase (GST) activity in modulating the cytotoxicity of four platinum drugs and… (More)
  • figure 1
  • table I
  • table II
  • figure 2
  • figure 3
Is this relevant?
1990
1990
Twenty-three serially transplantable ovarian carcinoma xenografts have been established in female nude mice from forty-two donor… (More)
Is this relevant?
1988
1988
A 6.4-fold cis-diamminedichloroplatinum(II) (CDDP) resistant human small cell lung carcinoma cell line (GLC4-CDDP) was developed… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • table 4
Is this relevant?