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oncostatin M

Known as: OSM, Oncostatin M [Chemical/Ingredient], Oncostatin-M 
A cytokine with both pro- and anti-inflammatory actions that depend upon the cellular microenvironment. Oncostatin M is a 28 kDa monomeric… 
National Institutes of Health

Related topics

Related topics

18 relations

Broader (2)

Antineoplastic AgentsGrowth Inhibitors
Cell ProliferationCytokine GeneCytokine Receptor BindingCytokine Signaling

Papers overview

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Highly Cited
2018
Highly Cited
2018
Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice
Fibrosis is an important wound‐healing process in injured tissues, but excessive fibrosis is often observed in patients with… 
Review
2013
Review
2013
The Enigmatic Cytokine Oncostatin M and Roles in Disease
Oncostatin M is a secreted cytokine involved in homeostasis and in diseases involving chronic inflammation. It is a member of the… 
Highly Cited
2008
Highly Cited
2008
Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis
Oncostatin M (OSM), an IL-6 family cytokine, has been implicated in a number of biological processes including the induction of… 
Highly Cited
2002
Highly Cited
2002
Induction of Bone-Type Alkaline Phosphatase in Human Vascular Smooth Muscle Cells: Roles of Tumor Necrosis Factor-&agr; and Oncostatin M Derived From Macrophages
Inflammatory cells such as macrophages and T lymphocytes play an important role in vascular calcification associated with… 
Highly Cited
1999
Highly Cited
1999
Regulation of inflammatory responses by oncostatin M.
Oncostatin M (OM) is a pleiotropic cytokine produced late in the activation cycle of T cells and macrophages. In vitro it shares… 
Highly Cited
1999
Highly Cited
1999
Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis.
Embryonic liver is a transient site for definitive hematopoiesis. Along with maturation of the bone marrow and spleen… 
Highly Cited
1997
Highly Cited
1997
The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression*
Both astrocytes in the central nervous system and fibroblasts in somatic tissues are not only the major sources of extracellular… 
Highly Cited
1996
Highly Cited
1996
Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK‐STAT5 pathway.
Oncostatin M (OSM) is a member of the interleukin‐6 (IL6)‐related cytokine subfamily that includes IL6, IL11, leukemia inhibitory… 
Highly Cited
1993
Highly Cited
1993
Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture.
Tissue inhibitor of metalloproteinases (TIMP-1) is a potent inhibitor of activated matrix metalloproteinases (MMP) such as… 
Highly Cited
1989
Highly Cited
1989
Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M
Oncostatin M is a polypeptide of Mr approximately 28,000 that acts as a growth regulator for many cultured mammalian cells. We… 
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