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oncostatin M

Known as: OSM, Oncostatin M [Chemical/Ingredient], Oncostatin-M 
A cytokine with both pro- and anti-inflammatory actions that depend upon the cellular microenvironment. Oncostatin M is a 28 kDa monomeric… 
National Institutes of Health

Related topics

Related topics

18 relations

Broader (2)

Antineoplastic AgentsGrowth Inhibitors
Cell ProliferationCytokine GeneCytokine Receptor BindingCytokine Signaling

Papers overview

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2009
2009
Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis.
OBJECTIVE To investigate the molecular mechanisms of CCL13/monocyte chemoattractant protein 4 (MCP-4) chemokine expression… 
2006
2006
Divergent effects of oncostatin M on astroglioma cells: Influence on cell proliferation, invasion, and expression of matrix metalloproteinases
Oncostatin M (OSM), a cytokine of the interleukin‐6 (IL‐6) family, can either promote or inhibit cell growth in various normal… 
2004
2004
Cytokines regulate the affinity of soluble CD44 for hyaluronan
Highly Cited
2003
Highly Cited
2003
Oncostatin M Regulates Eotaxin Expression in Fibroblasts and Eosinophilic Inflammation in C57BL/6 Mice1
Oncostatin M (OSM) is a member of the IL-6/LIF (or gp130) cytokine family, and its potential role in inflammation is supported by… 
Highly Cited
2000
Highly Cited
2000
Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: synergy with dexamethasone.
The role of oncostatin M in bone metabolism is not clearly defined, and the actions of mouse oncostatin M (mOSM) on osteoclast… 
Highly Cited
1999
Highly Cited
1999
Blocking signaling through the gp130 receptor chain by interleukin‐6 and oncostatin M inhibits PC‐3 cell growth and sensitizes the tumor cells to etoposide and cisplatin‐mediated cytotoxicity
The mechanisms of drug resistance associated with advanced, hormone‐independent prostate carcinoma are poorly understood. The… 
1999
1999
Adenovirus vector expressing mouse oncostatin M induces acute-phase proteins and TIMP-1 expression in vivo in mice.
Mouse oncostatin M (MuOSM) regulates the production of acute-phase proteins by hepatocytes as well as tissue inhibitor of… 
Highly Cited
1997
Highly Cited
1997
Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1-induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro.
OBJECTIVE To measure levels of oncostatin M (OSM) in the synovial fluid of rheumatoid arthritis (RA) patients and to examine the… 
1996
1996
Oncostatin M (OSM) stimulates resorption and inhibits synthesis of proteoglycan in porcine articular cartilage explants.
Oncostatin M (OSM) is structurally and functionally similar to leukaemia inhibitory factor (LIF), interleukin 6 (IL-6… 
1995
1995
The gp 130 family cytokines IL‐6, LIF and OSM but not IL‐11 can reverse the anti‐proliferative effect of dexamethasone on human myeloma cells
Summary. In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma (MM), three IL‐6… 
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