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A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors.
TLDR
A novel gene, CIS (cytokine inducible SH2‐containing protein), which is induced in hematopoietic cells by a subset of cytokines but not by stem cell factor, granulocyte colony‐stimulating factor and IL6 is isolated.
The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells
TLDR
The mitochondrial bottleneck is not due to a drastic decline in mtDNA copy number in early oogenesis but rather to a small effective number of segregation units for mtDNA in mouse germ cells, which provides new information formtDNA segregation models and for understanding the recurrence risks for mt DNA diseases.
Generation of transgenic rats expressing green fluorescent protein in S-100beta-producing pituitary folliculo-stellate cells and brain astrocytes.
TLDR
The generation of transgenic rats expressing green fluorescent protein (GFP) under the control of S-100beta protein gene promoter may allow the detection of living FS cells, which may be an excellent tool for the study of FS cells.
Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK‐STAT5 pathway.
TLDR
Molecular cloning of murine OSM as an immediate early gene induced by a subset of cytokines including IL2, IL3 and erythropoietin (EPO) in myeloid and lymphoid cell lines provides a new insight into the physiological function of this unique cytokine.
Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice.
TLDR
Unlike hOSM, mOSM and mLIF do not share the same functional receptor, and mOSm delivers signals only through its specific receptor complex, which indicates that the physiological roles of OSM are still unknown.
A Novel Oncostatin M-inducible Gene OIG37 Forms a Gene Family with MyD118 and GADD45 and Negatively Regulates Cell Growth*
TLDR
The novel OSM-inducible gene OIG37, related to MyD118 and GADD45, is described that suppressed cell growth without any evidence of apoptosis and associates with p21, a cyclin-dependent kinase inhibitor, and proliferating cell nuclear antigen.
In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region.
TLDR
Oncostatin M (OSM) is demonstrated to be a key cytokine for the development of multipotential hematopoietic progenitors in the AGM, possibly acting on common precursor cells between HSCs and endothelial cells.
The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.
TLDR
The notion that the AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic P-Sp/AGM region supports the notion that hematopoietic progenitors are generated in this region.
Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit.
TLDR
The cloned mOSMRbeta gene constitutes an essential and species-specific receptor component of the functional mOSM receptor and is found to be located in the vicinity of the LIFRbeta locus in the proximal end of chromosome 15.
Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos.
TLDR
It is demonstrated that GATA-2 is expressed in the precursor of hematopoietic cells and works as a gatekeeper to preserve their immaturity.
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