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omacetaxine mepesuccinate

Known as: (2'R,3S,4S,5R)-(-)-homoharringtonine, Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester), Homoharringtonin 
A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect and transmit extracellular… Expand
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Review
2018
Review
2018
Plants face a combination of different abiotic stresses under field conditions which are lethal to plant growth and production… Expand
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Review
2013
Review
2013
The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two decades ago inaugurated a field that has… Expand
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Highly Cited
2008
Highly Cited
2008
Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated with tumorigenesis in a number of human… Expand
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Highly Cited
2006
Highly Cited
2006
Hedgehog and canonical Wnt/β-catenin signaling are implicated in development of the osteoblast, the bone matrix-secreting cell of… Expand
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Highly Cited
2005
Highly Cited
2005
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a… Expand
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Review
2004
Review
2004
The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation, with normal roles in embryonic… Expand
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Highly Cited
2002
Highly Cited
2002
Constitutive Hedgehog (Hh) pathway activity is associated with initiation of neoplasia, but its role in the continued growth of… Expand
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Highly Cited
2002
Highly Cited
2002
Mutations affecting the transmembrane proteins Patched (Ptc) or Smoothened (Smo) that trigger ligand-independent activity of the… Expand
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Highly Cited
1996
Highly Cited
1996
Hedgehog (Hh) proteins comprise a family of secreted signaling molecules essential for patterning a variety of structures in… Expand
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