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Harringtonines

Known as: Alkaloids, Cephalotaxus, Cephalotaxus Alkaloids, Cephalotaxine Alkaloids 
Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as… Expand
National Institutes of Health

Related topics

Related topics

26 relations

Narrower (15)

11-hydroxycephalotaxine4'-desmethylhomoharringtonineHH07AHVF protocol
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Broader (3)

AlkaloidsAntineoplastic AgentsAntineoplastic Agents, Phytogenic
In BloodProcess of secretionagonistsantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of… Expand
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Highly Cited
2012
Highly Cited
2012
Inhibition of Chikungunya Virus Replication by Harringtonine, a Novel Antiviral That Suppresses Viral Protein Expression
ABSTRACT Chikungunya virus (CHIKV) is a mosquito-transmitted virus that has reemerged as a significant public health threat in… Expand
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Highly Cited
2011
Highly Cited
2011
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. Here we present a… Expand
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Highly Cited
2001
Highly Cited
2001
An approach toward isoindolobenzazepines using the ammonium ylide/Stevens.
Ammonium ylides derived from the Cu(II)-catalyzed decomposition of alpha-diazo carbonyls tethered to tertiary amines underwent a… Expand
Highly Cited
1999
Highly Cited
1999
Trichothecene Mycotoxins Trigger a Ribotoxic Stress Response That Activates c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase and Induces Apoptosis*
The trichothecene family of mycotoxins inhibit protein synthesis by binding to the ribosomal peptidyltransferase site. Inhibitors… Expand
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1992
1992
Homoharringtonine in combination with cytarabine for patients with acute myelogenous leukemia.
Homoharringtonine (HHT) is one of several cephalotaxine alkaloids that has shown clinical efficacy in patients with acute… Expand
Highly Cited
1977
Highly Cited
1977
Inhibition of translation in eukaryotic systems by harringtonine.
The Cephalotaxus alkaloids harringtonine, homoharringtonine and isoharringtonine inhibit protein synthesis in eukaryotic cells… Expand
Highly Cited
1975
Highly Cited
1975
Harringtonine, an inhibitor of initiation of protein biosynthesis.
  • M. Huang
  • Molecular pharmacology
  • 1975
    • Corpus ID: 46688482
The Cephalotaxus alkaloid harringtonine inhibits protein biosynthesis in HeLa cells, intact rabbit reticulocytes, and… Expand
1972
1972
Deoxyharringtonine, a new antitumor alkaloid from Cephalotaxus: Structure and synthetic studies
Abstract A new alkaloid (proposed name, deoxyharringtonine) with significant antileukemic activity has been isolated from… Expand
Highly Cited
1970
Highly Cited
1970
Structures of harringtonine, isoharringtonine, and homoharringtonine.
 
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