FAQ

Harringtonines

Known as: Alkaloids, Cephalotaxus, Cephalotaxus Alkaloids, Cephalotaxine Alkaloids 
Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
051019702017

Related topics

Related topics

25 relations

Narrower (13)

4'-desmethylhomoharringtonineHH07AHarringtoninecephalezomine H
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Broader (2)

AlkaloidsAntineoplastic Agents
In BloodProcess of secretionadministration & dosageagonists
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Harringtonines
physiological aspects
agonists
Alkaloids
Antineoplastic Agents
omacetaxine mepesuccinate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression.
Chikungunya virus (CHIKV) is a mosquito-transmitted virus that has reemerged as a significant public health threat in the last… (More)
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Highly Cited
2012
Highly Cited
2012
The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of… (More)
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Highly Cited
2011
Highly Cited
2011
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. Here we present a… (More)
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2004
2004
[Proteome analysis of apoptotic K562 cells induced by harringtonine].
OBJECTIVE To screen and identify apoptosis related proteins and explore the mechanism of harringtonine (HT)-induced K562 cells… (More)
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2003
2003
Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in several human tumors both in vitro and in… (More)
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1998
1998
Role of calcium in apoptosis of HL-60 cells induced by harringtonine
The effect of Ca2+ on HT-induced apoptosis in HL-60 cells was examined. Characteristics of apoptosis induced by harringtonine (HT… (More)
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1996
1996
Reduction of doxorubicin resistance by tetrandrine and dauricine in harringtonine-resistant human leukemia (HL60) cells.
AIM To study whether tetrandrine (Tet) and dauricine (Dau) can reduce doxorubicin (Dox) resistance in the harringtonine (Har… (More)
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1985
1985
Biologic and pharmacologic effects of harringtonine on human leukemia-lymphoma cells
Ten human leukemia-lymphoma cell lines were tested for the growth-inhibitory effects of harringtonine (HT). HT was most active… (More)
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1983
1983
Uptake, initial effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensitive and resistant to vincristine and other chemotherapeutic agents.
[3H]Harringtonine was shown to be taken up rapidly by L1210/0 cells using a fast-mixing, fast-separating technique and was… (More)
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Highly Cited
1977
Highly Cited
1977
Inhibition of translation in eukaryotic systems by harringtonine.
The Cephalotaxus alkaloids harringtonine, homoharringtonine and isoharringtonine inhibit protein synthesis in eukaryotic cells… (More)
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