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Harringtonines

Known as: Alkaloids, Cephalotaxus, Cephalotaxus Alkaloids, Cephalotaxine Alkaloids 
Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as… Expand
National Institutes of Health

Related topics

Related topics

26 relations

Narrower (15)

11-hydroxycephalotaxine4'-desmethylhomoharringtonineHH07AHVF protocol
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Broader (3)

AlkaloidsAntineoplastic AgentsAntineoplastic Agents, Phytogenic
In BloodProcess of secretionagonistsantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Local adaptation to temperature and precipitation in naturally fragmented populations of Cephalotaxus oliveri, an endangered conifer endemic to China
Cephalotaxus oliveri is an endangered tertiary relict conifer endemic to China. The species survives in a wide range from west to… Expand
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Highly Cited
2013
Highly Cited
2013
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression.
Chikungunya virus (CHIKV) is a mosquito-transmitted virus that has reemerged as a significant public health threat in the last… Expand
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Highly Cited
2012
Highly Cited
2012
The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of… Expand
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Highly Cited
2012
Highly Cited
2012
Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution.
Understanding translational control in gene expression relies on precise and comprehensive determination of translation… Expand
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Highly Cited
2011
Highly Cited
2011
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. Here we present a… Expand
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2003
2003
New alkaloids from Cephalotaxus fortunei.
Four new cephalotaxus alkaloids, cephalotaxine alpha-N-oxide (1), cephalotaxine beta-N-oxide (2), 11-beta-hydroxycephalotaxine… Expand
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Highly Cited
1999
Highly Cited
1999
Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis.
The trichothecene family of mycotoxins inhibit protein synthesis by binding to the ribosomal peptidyltransferase site. Inhibitors… Expand
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1992
1992
Homoharringtonine in combination with cytarabine for patients with acute myelogenous leukemia.
Homoharringtonine (HHT) is one of several cephalotaxine alkaloids that has shown clinical efficacy in patients with acute… Expand
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Highly Cited
1977
Highly Cited
1977
Inhibition of translation in eukaryotic systems by harringtonine.
The Cephalotaxus alkaloids harringtonine, homoharringtonine and isoharringtonine inhibit protein synthesis in eukaryotic cells… Expand
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Highly Cited
1975
Highly Cited
1975
Harringtonine, an inhibitor of initiation of protein biosynthesis.
The Cephalotaxus alkaloid harringtonine inhibits protein biosynthesis in HeLa cells, intact rabbit reticulocytes, and… Expand
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