obatoclax

Known as: 1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)- 
A small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Obatoclax (GX15-070), a small-molecule inhibitor of antiapoptotic Bcl-2 proteins, has been reported to trigger cell death via… (More)
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2012
2012
Prior studies demonstrated that resistance to the ERBB1/2 inhibitor lapatinib could be overcome by the B cell CLL/lymphoma-2 (BCL… (More)
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2010
2010
Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for… (More)
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Highly Cited
2010
Highly Cited
2010
In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children… (More)
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Highly Cited
2010
Highly Cited
2010
Glucocorticoids (GCs) are common components of many chemotherapeutic regimens for lymphoid malignancies including acute… (More)
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2009
2009
PURPOSE Prosurvival Bcl-2 proteins inhibit the mitochondrial and death receptor-mediated apoptotic pathways. Obatoclax is a small… (More)
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2009
2009
Past studies have shown that melanoma cells have largely adapted to endoplasmic reticulum (ER) stress, and this is associated… (More)
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Highly Cited
2008
Highly Cited
2008
In this study, we investigated the mechanism of apoptosis induction of obatoclax (GX15-070), a novel Bcl-2 homology domain-3 (BH3… (More)
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Highly Cited
2007
Highly Cited
2007
Elevated expression of members of the BCL-2 pro-survival family of proteins can confer resistance to apoptosis in cancer cells… (More)
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Highly Cited
2007
Highly Cited
2007
Bcl family members Bcl-2, Bcl-x(L), and Mcl-1, are frequently expressed and implicated in the survival of myeloma cells… (More)
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