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obatoclax

Known as: 1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)- 
A small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding… 
National Institutes of Health

Related topics

Related topics

4 relations
Apoptosis Promoterobatoclax mesylate

Narrower (1)

GX 15-070

Broader (1)

Pyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer
Although the prognosis of differentiated thyroid cancer (DTC) is relatively good, 30-40% of patients with distant metastases… 
Highly Cited
2017
Highly Cited
2017
THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
Peripheral T-cell lymphomas (PTCL) are aggressive diseases with poor response to chemotherapy and dismal survival. Identification… 
2014
2014
Up-regulation of cyclinD1 and Bcl2A1 by insulin is involved in osteoclast proliferation.
Review
2013
Review
2013
Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics.
2013
2013
Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down‐regulation of Mcl‐1 in mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive form of Non‐Hodgkin‐lymphoma (NHL) with an ongoing need for novel treatments. Apart… 
Highly Cited
2012
Highly Cited
2012
Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells.
2012
2012
Lapatinib and Obatoclax Kill Tumor Cells through Blockade of ERBB1/3/4 and through Inhibition of BCL-xL and MCL-1
Prior studies in breast cancer cells have shown that lapatinib and obatoclax interact in a greater than additive fashion to cause… 
Highly Cited
2011
Highly Cited
2011
Distinct cellular and therapeutic effects of obatoclax in rituximab‐sensitive and ‐resistant lymphomas
Bcl‐2 proteins represent a rheostat that controls cellular viability. Obatoclax, a BH3‐mimetic, has been designed to specifically… 
2011
2011
Optimization of circulating biomarkers of obatoclax-induced cell death in patients with small cell lung cancer.
Small cell lung cancer (SCLC) is an aggressive disease in which, after initial sensitivity to platinum/etoposide chemotherapy… 
Highly Cited
2009
Highly Cited
2009
Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
Prior studies demonstrated that resistance to the ERBB1/2 inhibitor Lapatinib in HCT116 cells was mediated by increased MCL-1… 
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