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ob/ob Mouse

Known as: ob/ob 
The obese mutant mouse was derived from a spontaneous mutation in a V/Le progenitor mouse at the Jackson Laboratory in 1949.
National Institutes of Health

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2009
Highly Cited
2009
A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss.
In mice of normal weight and with diet-induced obesity, a high-fat, low-carbohydrate ketogenic diet (KD) causes weight loss… 
Highly Cited
2008
Highly Cited
2008
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
Background:Obesity is currently viewed as a state of chronic low-grade inflammation in which there is a pro-inflammatory… 
Highly Cited
2006
Highly Cited
2006
KiSS‐1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse
Leptin is an adipocyte‐derived hormone that acts on the hypothalamus to influence feeding, metabolism and reproduction, but the… 
Highly Cited
2004
Highly Cited
2004
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity*
Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported… 
Highly Cited
2003
Highly Cited
2003
Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis*
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and… 
Highly Cited
1999
Highly Cited
1999
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice.
Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours' starvation of normal mice reduced the total thymocyte… 
Highly Cited
1998
Highly Cited
1998
An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene.
Adenoviral (Ad)-mediated in vivo gene transfer and expression are limited in part by cellular immune responses to viral-encoded… 
Highly Cited
1997
Highly Cited
1997
Leptin increases uncoupling protein expression and energy expenditure.
In ob/ob mice, leptin increases energy expenditure and sympathetic outflow to brown adipose tissue (BAT). To test whether the… 
Highly Cited
1995
Highly Cited
1995
Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.
To determine whether the product of the recently cloned ob gene functions as an adipose-related satiety factor, recombinant… 
Highly Cited
1978
Highly Cited
1978
beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa).
Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa… 
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