Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice.

@article{Howard1999LeptinPM,
  title={Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice.},
  author={Jane K. Howard and Graham M Lord and Giuseppe Matarese and Silvia Vendetti and Mohammad A. Ghatei and Mary A. Ritter and R. Lechler and Stephen R. Bloom},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={104 8},
  pages={1051-9}
}
Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours' starvation of normal mice reduced the total thymocyte count to 13% of that observed in freely fed controls, predominantly because of a diminution in the cortical CD4(+)CD8(+) thymocyte subpopulation. Prevention of the fasting-induced fall in the level of the adipocyte-derived hormone leptin by administering exogenous recombinant leptin protected mice from these starvation-induced thymic changes. The ob/ob mouse, which is… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 217 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…