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The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are… Expand The liver is the major site of biotransformation for most opioids. Thus, the disposition of these drugs may be affected in… Expand A standard dose of 100 mg of pethidine was given im to 13 healthy primiparae during labour. The aim of the study was to… Expand SummaryPatients with renal insufficiency commonly require the administration of an opioid analgesic to provide adequate pain… Expand Patient-controlled analgesia (PCA) with i.v. opioids is prescribed increasingly. We report three cases of norpethidine toxicity… Expand Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity… Expand The analgesic meperidine has been reported to produce signs of central nervous system excitation in human beings. To determine… Expand In an attempt to improve postoperative pain management an intravenous infusion of pethidine was designed to provide stable… Expand Concentrations of meperidine and its active metabolite, normeperidine, were measured in plasma of patients receiving the drug for… Expand SummaryDrugs that are administered to man may be biotransformed to yield metabolites that are pharmacologically active. The… Expand