nemorubicin

A morpholinyl analogue of the anthracycline doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450 CYP3A enzyme to a… (More)

Topic mentions per year

Topic mentions per year

2001-2016
01220012016

Papers overview

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2017
2017
The DNA alkylating mechanism of PNU-159682 (PNU), a highly potent metabolite of the anthracycline nemorubicin, was investigated… (More)
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2016
2016
BACKGROUND Intra-molecular G-quadruplex structures are present in the guanine rich regions of human telomeres and were found to… (More)
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2012
2012
The antitumor anthracycline nemorubicin is converted by human liver microsomes to a major metabolite, PNU-159682 (PNU), which was… (More)
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2010
2010
Drug resistance is one of the major obstacles limiting the activity of anticancer agents. Activation of DNA repair mechanism… (More)
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2009
2009
Preclinical and clinical studies of CYP gene-directed enzyme prodrug therapy have been focused on anticancer prodrugs activated… (More)
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2009
2009
4593 Background: Nemorubicin is a novel DNA-intercalator, mainly metabolized in liver by CYP3A4 enzyme and showing synergic… (More)
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2008
2008
We recently demonstrated that nemorubicin (MMDX), an investigational antitumor drug, is converted to an active metabolite, PNU… (More)
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2008
2008
Nemorubicin is a 3'-deamino-3'[2-(S)-methoxy-4-morpholinyl]derivative of doxorubicin. This derivative has been synthesized in the… (More)
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2005
2005
PURPOSE Nemorubicin (3'-deamino-3'-[2''(S)-methoxy-4''-morpholinyl]doxorubicin; MMDX) is an investigational drug currently in… (More)
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2002
2002
A selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS-MS) method for quantitative determination of… (More)
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