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nelarabine

Known as: 2-Amino-6-methoxypurine arabinoside, 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, 2-Amino, 6-Methoxypurine Arabinoside 
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9… Expand
National Institutes of Health

Related topics

Related topics

7 relations

Broader (1)

Arabinonucleosides

Narrower (3)

ArranonGW-506U78GW506U78
DNADNA Synthesis InhibitionNCIt Antineoplastic Agent Terminology

Papers overview

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Highly Cited
2017
Highly Cited
2017
Calibration of the dolomite clumped isotope thermometer from 25 to 350 °C, and implications for a universal calibration for all (Ca, Mg, Fe)CO3 carbonates
Carbonate clumped isotope thermometry is based on the temperature-dependent formation of ^(13)C^(18)O^(16)O_2^(2-) ion groups… Expand
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2015
2015
Safe integration of nelarabine into intensive chemotherapy in newly diagnosed T-cell acute lymphoblastic leukemia: Children's Oncology Group Study AALL0434.
BACKGROUND Nelarabine has shown impressive single agent clinical activity in T-cell acute lymphoblastic leukemia (T-ALL), but has… Expand
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Highly Cited
2013
Highly Cited
2013
Telocytes and stem cells in limbus and uvea of mouse eye
The potential of stem cell (SC) therapies for eye diseases is well-recognized. However, the results remain only encouraging as… Expand
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Highly Cited
2012
Highly Cited
2012
High temporal and spatial variability of dissolved oxygen and pH in a nearshore California kelp forest
Abstract. Predicting consequences of ocean deoxygenation and ocean acidification for nearshore marine ecosystems requires… Expand
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Highly Cited
2012
Highly Cited
2012
Pilot study of nelarabine in combination with intensive chemotherapy in high-risk T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.
PURPOSE Children's Oncology Group study AALL00P2 was designed to assess the feasibility and safety of adding nelarabine to a BFM… Expand
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Highly Cited
2011
Highly Cited
2011
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation.
Nelarabine, a purine analog with T-cell specific action, has been approved for relapsed/refractory T-cell acute lymphoblastic… Expand
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Highly Cited
2007
Highly Cited
2007
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801.
Nelarabine (506U78) is a soluble pro-drug of 9-beta-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative. We treated 26… Expand
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Highly Cited
2007
Highly Cited
2007
G-quadruplex induced stabilization by 2′-deoxy-2′-fluoro-d-arabinonucleic acids (2′F-ANA)
The impact of 2′-deoxy-2′-fluoroarabinonucleotide residues (2′F-araN) on different G-quadruplexes derived from a thrombin-binding… Expand
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Highly Cited
2005
Highly Cited
2005
Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group.
PURPOSE Nelarabine (compound 506U78), a water soluble prodrug of 9-b-d-arabinofuranosylguanine, is converted to ara-GTP in T… Expand
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Highly Cited
2004
Highly Cited
2004
Influence of cattle breed and ageing time on textural meat quality.
An experiment was carried out using 7 month old male calves from four different breeds: 10 Spanish Holstein (dairy), 10 Old Brown… Expand
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