nelarabine

Known as: 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, 2-Amino, 6-Methoxypurine Arabinoside, nelarabine [Chemical/Ingredient] 
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9… (More)

Topic mentions per year

Topic mentions per year

1975-2018
05101519752018

Papers overview

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2011
2011
Nelarabine, a purine analog with T-cell specific action, has been approved for relapsed/refractory T-cell acute lymphoblastic… (More)
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2010
2010
A 30–year-old man was diagnosed with ALL T-lineage immunophenotype, (CD71, CD131, CD451, MPO-), normal karyotype, with no CNS… (More)
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2008
2008
PURPOSE To test whether nelarabine is an effective agent for indolent leukemias and to evaluate whether there is a relationship… (More)
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Highly Cited
2007
Highly Cited
2007
Nelarabine (506U78) is a soluble pro-drug of 9-beta-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative. We treated 26… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Nelarabine (compound 506U78), a water soluble prodrug of 9-b-d-arabinofuranosylguanine, is converted to ara-GTP in T… (More)
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2001
2001
PURPOSE A pilot protocol was designed to evaluate the efficacy of fludarabine with nelarabine (the prodrug of arabinosylguanine… (More)
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2000
2000
PURPOSE To characterize the pharmacokinetics of nelarabine (506U78), the water-soluble prodrug of 9-beta-D-arabinofuranosyl… (More)
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1996
1996
Most patients requiring allogeneic bone marrow transplantation (BMT) lack a human leukocyte antigen genotypically identical… (More)
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1995
1995
Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated… (More)
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