FAQ

nelarabine

Known as: 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine, 2-Amino, 6-Methoxypurine Arabinoside, nelarabine [Chemical/Ingredient] 
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9… (More)

Topic mentions per year

Topic mentions per year

1975-2018
05101519752018

Related topics

Related topics

5 relations

Broader (1)

Arabinonucleosides

Narrower (2)

ArranonGW506U78
DNAEnzyme Inhibition

Related mentions per year

Related mentions per year

1947-2018
19401960198020002020
nelarabine
DNA
Enzyme Inhibition
Arabinonucleosides
GW506U78
Arranon

Papers overview

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2013
2013
Turning off the inflammatory, but not the metabolic, flames
 
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2011
2011
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation.
Nelarabine, a purine analog with T-cell specific action, has been approved for relapsed/refractory T-cell acute lymphoblastic… (More)
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2010
2010
Complete paraplegia after nelarabine treatment in a T-cell acute lymphoblastic leukemia adult patient.
A 30–year-old man was diagnosed with ALL T-lineage immunophenotype, (CD71, CD131, CD451, MPO-), normal karyotype, with no CNS… (More)
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2008
2008
Phase I trial of nelarabine in indolent leukemias.
PURPOSE To test whether nelarabine is an effective agent for indolent leukemias and to evaluate whether there is a relationship… (More)
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Highly Cited
2007
Highly Cited
2007
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801.
Nelarabine (506U78) is a soluble pro-drug of 9-beta-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative. We treated 26… (More)
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Highly Cited
2005
Highly Cited
2005
Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group.
PURPOSE Nelarabine (compound 506U78), a water soluble prodrug of 9-b-d-arabinofuranosylguanine, is converted to ara-GTP in T… (More)
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2001
2001
Evaluation of the combination of nelarabine and fludarabine in leukemias: clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells.
PURPOSE A pilot protocol was designed to evaluate the efficacy of fludarabine with nelarabine (the prodrug of arabinosylguanine… (More)
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2000
2000
Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies.
PURPOSE To characterize the pharmacokinetics of nelarabine (506U78), the water-soluble prodrug of 9-beta-D-arabinofuranosyl… (More)
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1996
1996
Combined in vitro and in vivo T lymphocyte depletion for the control of graft-versus-host disease following haploidentical marrow transplant.
Most patients requiring allogeneic bone marrow transplantation (BMT) lack a human leukocyte antigen genotypically identical… (More)
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1995
1995
2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.
Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated… (More)
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