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negative regulation of tau-protein kinase activity

Known as: downregulation of protein tau kinase activity, downregulation of tau protein kinase activity, down regulation of tau kinase activity 
Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity. [GO_REF:0000059, GOC:sjp, GOC:TermGenie… 
National Institutes of Health

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4 relations

Broader (1)

biological control
down regulation of TPK IIdown regulation of TTKtau-protein kinase activity

Papers overview

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Highly Cited
2017
Highly Cited
2017
Hsp90 activator Aha1 drives production of pathological tau aggregates
Significance The accumulation of toxic tau protein, as in Alzheimer’s disease, is regulated by the 90-kDa heat shock protein… 
Highly Cited
2011
Highly Cited
2011
Oleuropein and derivatives from olives as Tau aggregation inhibitors
Highly Cited
2011
Highly Cited
2011
Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease.
Alzheimer's disease is a neurodegenerative disorder involving extracellular plaques (amyloid-β) and intracellular tangles of tau… 
Highly Cited
2009
Highly Cited
2009
Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the… 
Highly Cited
2006
Highly Cited
2006
Neuronal Pentraxin 1 Contributes to the Neuronal Damage Evoked by Amyloid-β and Is Overexpressed in Dystrophic Neurites in Alzheimer's Brain
Accumulation of amyloid-β (Aβ) is thought to play a central role in the progressive loss of synapses, the neurite damage, and the… 
Highly Cited
2005
Highly Cited
2005
Inhibition of LPS-induced NO production by taurine chloramine in macrophages is mediated though Ras-ERK-NF-kappaB.
Highly Cited
1999
Highly Cited
1999
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.
Accumulation of paired helical filaments (PHFs) in neurofibrillary tangles, neuropil threads, and dystrophic neurites is one of… 
Highly Cited
1997
Highly Cited
1997
Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ.
Microinjection of plasmids encoding human tau (htau) protein into identified lamprey reticulospinal neurons (anterior bulbar… 
Review
1995
Review
1995
Hyperphosphorylation of Tau in PHF
Highly Cited
1995
Highly Cited
1995
Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments.
The major components of neurofibrillary tangles (NFT) in Alzheimer's disease are bundles of paired helical filaments (PHF) which… 
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