negative regulation of tau-protein kinase activity

Known as: downregulation of protein tau kinase activity, downregulation of tau protein kinase activity, down regulation of tau kinase activity 
Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity. [GO_REF:0000059, GOC:sjp, GOC:TermGenie… (More)
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the progression of neurodegenerative diseases… (More)
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Highly Cited
2013
Highly Cited
2013
Amyloid-β 1-42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and hippocampal neurons and might play a role in early… (More)
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Highly Cited
2011
Highly Cited
2011
Neurofibrillary tangles (NFTs) in Alzheimer disease and related tauopathies are composed of insoluble hyperphosphorylated Tau… (More)
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Highly Cited
2009
Highly Cited
2009
Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including… (More)
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Highly Cited
2009
Highly Cited
2009
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the… (More)
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Highly Cited
2001
Highly Cited
2001
Intraneuronal filamentous tau inclusions such as neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's… (More)
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Highly Cited
1999
Highly Cited
1999
Accumulation of paired helical filaments (PHFs) in neurofibrillary tangles, neuropil threads, and dystrophic neurites is one of… (More)
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Highly Cited
1995
Highly Cited
1995
To gain insight into the abnormal phosphorylation of PHF-tau, we have determined the phosphorylation sites by identifying… (More)
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Review
1995
Review
1995
Tau in PHF is known to be highly phosphorylated and immunochemical study has indicated the similarity of the phosphorylation… (More)
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Highly Cited
1992
Highly Cited
1992
We performed phosphate analysis of tau proteins isolated from normal human brain, tau proteins associated with paired helical… (More)
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